Here's part of our conversation with infectious disease specialist Dr. Michelle Barron (of CU School of Medicine): On the Omicron-specific booster: "It's Omicron specific, BA.4 and BA.5, which is what we've been seeing for the last several month circulating. The other booster previous to this and original vaccine were based on the original strain of COVID. This one in theory will give you a little bit broader protection because it's more specific to what were seeing," Barron said.