“Ear infections are by far the most common reason that children in the U.S. are prescribed antibiotics,” Holly M. Frost, senior director of the Center for Health Systems Research at Denver Health [and associate professor of pediatrics at CU School of Medicine], told Healio. “By the time a child is 5 years old, 80% of them will have had at least one ear infection, and a quarter of them will have had three or more.”