GLP-1 agonists improve insulin resistance and lead to weight loss, so it makes sense that they also improve PCOS symptoms, added Melanie Cree, director of the multidisciplinary PCOS Clinic at Children’s Hospital Colorado. “It is completely being used now with no evidence because the [obstetrics] field knows that if you have 5% weight loss in these individuals with PCOS, you will improve fertility,” she said.