Virginia F. Borges, MD, MMSc, a professor of medicine in the Division of Medical Oncology at the University of Colorado School of Medicine and a medical oncologist at the UCHealth Diane O'Connor Thompson Breast Center, Anschutz Medical Campus, and colleagues (Peter Kabos, MD, Elena Shagisultanova, MD, PhD, Radhika Acharya-Leon, DO, Jennifer Diamond, MD and Marie Wood, MD) highlight updates across the breast cancer landscape, including key updates from the 2022 SABCS.