Down syndrome, also known as trisomy 21, is caused by an extra copy of chromosome 21 and is the most common chromosomal abnormality in the population. Research shows individuals with Down syndrome often experience widespread immune dysregulation and inflammation that can lead to many different co-occurring conditions including issues in the gut. Many are diagnosed with several types of gastrointestinal (GI) motility issues such as celiac disease, irritable bowel syndrome and chronic constipation during their lifetime.
A study recruiting participants with Down syndrome and chronic constipation offers comprehensive, immediate care while also helping scientists learn more about the condition.
Leaders of the study, Jaime Belkind-Gerson, MD, MSc, pediatric gastroenterologist and director of the Neurogastroenterology and Motility Program at Children’s Hospital Colorado and Kelly Sullivan, PhD, assistant professor of pediatrics and leader of the Experimental Models Program at the Linda Crnic Institute for Down Syndrome, answer questions about this research opportunity and give insight into treatment options. Anyone interested in the study can reach out to the clinical team by email at htp@ucdenver.edu.