Colocalization of Gene Expression and DNA Methylation with Genetic RiskVariants Supports Functional Roles of MUC5B and DSP in Idiopathic Pulmonary Fibrosis

Common genetic variants have been associated with idiopathic pulmonary fibrosis (IPF). We have established a relationship of the common IPF genetic risk variants rs35705950 and rs2076295 with respective changes in MUC5B and DSP expression and methylation. These results provide additional evidence that both MUC5B and DSP are involved in the etiology of IPF.