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Blogs

Research Data analysis

CU Data Researchers Connect Diet to Changes in the Microbiome

“Should I be taking a probiotic?” is a question that Maggie Stanislawski, PhD, assistant professor in the University of Colorado Department of Biomedical Informatics (DBMI), gets asked often.  

Research    Data analysis

How Software Gardening Can Benefit Researchers

While software development has long been compared to the craft of carpentry due to the need for a sturdy foundation and clear instructions, many in the field say garden analogies offer a way to address gaps and enhance practices.


Author Kara Mason | Publish Date September 28, 2023
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Research    DNA    Genetics

Why Do Zebrafish Make Model Organisms in Scientific Research?

At first glance, there don’t seem to be many similarities between humans and zebrafish, but the small freshwater minnows native to southeastern Asia have quickly become a favorite model organism in scientific research, allowing researchers to study human health, rare diseases, and treatment options.


Author Kara Mason | Publish Date September 26, 2023
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DNA    Genetics    Data analysis

What is Genomics?

Genes are at the center of nearly every human disease and symptom, and until the past few decades, medical researchers had a much narrower interpretation of the human body’s entire genetic makeup, also called the genome.


Author Kara Mason | Publish Date August 30, 2023
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Research    Awareness    Climate Science

Summer Heat Gives Rise to Algal Blooms and Health Concerns

Hot summer days and a large body of water might sound like a recipe for relief when temperatures soar, but the same conditions can make lakes, ponds, and inland swim beaches the ideal place for harmful algal bloom (HAB) events to flourish.


Author Kara Mason | Publish Date August 21, 2023
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Research    Data analysis

CU Data Researchers Connect Diet to Changes in the Microbiome

“Should I be taking a probiotic?” is a question that Maggie Stanislawski, PhD, assistant professor in the University of Colorado Department of Biomedical Informatics (DBMI), gets asked often.  


Author Kara Mason | Publish Date August 17, 2023
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Patient Care    Community   

More Than 200 CU Faculty Members Recognized as 5280 Magazine Top Doctors for 2023

Denver-area magazine 5280 released its list of top doctors for 2023, and CU School of Medicine faculty members continue to be ranked among the best. Congratulations to the more than 200 CU School of Medicine faculty members honored with the title "Top Doctor."


Author School of Medicine | Publish Date July 31, 2023
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Research    Advancement    Data analysis

Altitude Research Reaches New Heights

Anybody who has ever experienced altitude sickness, even the mildest form known as acute mountain sickness, knows how debilitating it can be. Symptoms, which include lightheadedness, nausea, fatigue, and headache, most often occur at altitudes above 8,000 feet.


Author Kara Mason | Publish Date July 25, 2023
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Research    Genetics

How Trustworthy is Your Dog’s DNA Test?

Lila is a registered purebred beagle, but depending on what company does her DNA testing, she might be part rottweiler, part American foxhound, or not a beagle at all.


Author Kara Mason | Publish Date July 18, 2023
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Research    Rheumatoid Arthritis    Data analysis

CU Data Scientist Receives Funds to Study Precision Medicine for Rheumatoid Arthritis

With no cure or widely successful therapeutic options for patients with rheumatoid arthritis (RA), Fan Zhang, PhD, is looking to computational machine learning to identify new target treatments.


Author Kara Mason | Publish Date July 12, 2023
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Research    Advancement    Genetics

A Taste of the Future: CU Researcher Links Genetics with Dietary Intake

For geneticist Joanne Cole, PhD, food is life. Her love goes beyond trying a new recipe and seeking out new restaurants it’s also in her work in the University of Colorado Department of Biomedical Informatics (DBMI), identifying the connection between genetics and nutrition.


Author Kara Mason | Publish Date July 09, 2023
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Equity Diversity and Inclusion    Conferences

Increasing Accessibility for Parents, Caregivers at Data Conferences

Casey Greene, PhD, has a lot of tips for fellow scientists traveling with young children to conferences: invest in a good backpack over a diaper bag, always ask the hotel for a crib, and schedule the flight with a connection – it’ll give you time to change a diaper and feed.


Author Kara Mason | Publish Date June 27, 2023
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Research    Clinical Informatics

Leveraging Patient Identity Management Systems to Improve Global Health

Being able to follow a patient’s progression through a health system is an important factor for care in any nation, but it can be more difficult in developing countries that face greater technological and data-related challenges.


Author Kara Mason | Publish Date June 05, 2023
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Research    Diversity    Genetics

CU Researchers Weave Deeper Understanding of Diverse Ancestry and Gene Expression

Exploring diverse ancestry is a critical factor in furthering medical research.  

A new study published in Nature Genetics from researchers in the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine, in partnership with the University of California San Francisco and Stanford University, is the largest of its kind that focuses on ancestry correlations with biomedical traits and the first study to examine the role of genetic variants across diverse ancestries in regulating gene expression.


Author Kara Mason | Publish Date May 25, 2023
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Research    rare disease

CU Data Scientists Develop Rare Disease Phenopacket Standard, Tools For Global Use

Researchers in the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine have reached a major milestone in developing standards and tools for creating phenopackets that may foster more innovation and advancement in the medical field by allowing health professionals to more easily collect and share data.


Author Kara Mason | Publish Date May 17, 2023
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Research    Equity Diversity and Inclusion    Data analysis

Researchers Amplify Diverse Sourcing in Science Journalism

Following an analysis of more than 20,000 articles by researchers in the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine, a major science publication is implementing new policies to improve the diversity of its sources.


Author Kara Mason | Publish Date April 05, 2023
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Research    rare disease

Rare Disease Day Event Explores Possibility of Regional Hub on the CU Anschutz Medical Campus

The University of Colorado Anschutz Medical Campus celebrated the global Rare Disease Day on February 28 with an event that highlighted the campus' strengths in diagnosing and treating rare diseases and explored a vision for creating a regional rare disease hub.


Author Greg Glasgow | Publish Date March 01, 2023
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Research    Artificial Intelligence (AI)

AI-Assisted Authoring Tool Offers Timesaving and Transparency

As the world explores the new possibilities and uses of artificial intelligence (AI) tools like ChatGPT, researchers at the University of Colorado Department of Biomedical Informatics (DBMI) are integrating similar models into academic authoring.


Author Rachel Wittel | Publish Date February 22, 2023
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Research    Health equity    Clinical Informatics    Clinical decision support (CDS)

AI-Powered Tool Uses Hospital Nursing Notes to Save Lives

For years, David Albers, PhD, associate professor of biomedical informatics at University of Colorado School of Medicine, has been haunted by a friend’s death. It was long before Albers contemplated a career in health care, when he was an undergrad studying physics and taking music lessons in his spare time from accomplished jazz musician Tony Williams.


Author Toni Lapp | Publish Date January 31, 2023
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Press Releases   

Voting for U.S. News & World Report Hospitals Ranking

The University of Colorado School of Medicine is proud of our faculty's work that contributes to UCHealth's annual rankings on the U.S. News & World Report's Best Hospitals. These rankings are important as many students, residents, faculty, and patients consider these rankings when deciding where to train, practice and receive care.


Author School of Medicine | Publish Date January 19, 2023
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Research    Students    Obesity

Gene Expression Study Reveals New Molecular Associations with Obesity

New research from the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine has identified 45 genes whose gene expression is associated with body mass index (BMI), many of which have not been explored in obesity research before, after conducting a study using a multiethnic cohort.


Author Toni Lapp | Publish Date January 18, 2023
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Research    Community    COVID-19

How CU Data Scientists Are Debunking COVID-19 Misinformation

Researchers in the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine spearheaded an innovative method to synthesize and compile accurate information about COVID-19 since the onset of the global pandemic in 2020.


Author Toni Lapp | Publish Date January 12, 2023
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Research    Blood    Child & Adolescent

New Tool Provides Global Standard for Pediatric Blood Pressure Assessment

Using data from studies published in the medical literature over a 40-year time span, Peter DeWitt, PhD, a University of Colorado School of Medicine data scientist in the Department of Biomedical Informatics (DBMI), has developed an automated algorithm to address gaps in children’s blood pressure percentiles, providing a way to directly compare blood pressure measurements for children of the same age, sex, and height.


Author Toni Lapp | Publish Date December 12, 2022
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Research    Innovation    Faculty    Medical imaging

Novel Technology Designed to Increase MRI Speeds

Nicholas Dwork, PhD, assistant professor in the Department of Biomedical Informatics at the University of Colorado School of Medicine, has filed a provisional patent for a technology that could increase scan speeds of three-dimensional magnetic resonance imaging (MRI). The invention could lead to faster results, increase the clinical applications of MRIs, and ultimately improve patient care.


Author Toni Lapp | Publish Date December 05, 2022
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Research    Awards

CU Faculty Awarded $1.05 Million to Identify Family Relationships Using Electronic Health Data

Toan Ong, PhD, associate professor of biomedical informatics at the University of Colorado School of Medicine, has been approved for a $1.05 million funding award from the Patient-Centered Outcomes Research Institute (PCORI) for a project that will improve methods of conducting research using electronic health records (EHRs).


Author Toni Lapp | Publish Date November 28, 2022
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Research    Community    Equity Diversity and Inclusion

CU Professor Draws on Indigenous Roots in Approach to Research and Mentoring

From the University of Colorado Department of Biomedical Informatics (DBMI) offices on the top floor of the Anschutz Health Sciences Building, one sees sweeping views of Denver and the Rocky Mountains. DBMI Assistant Professor Katrina Claw, PhD, sees the lands that Native American tribes have called their home.


Author Toni Lapp | Publish Date November 21, 2022
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Community    Faculty    Diversity    Health equity    Social Justice

Breaking Barriers and Creating Opportunities for Underrepresented People in Data Science

Janani Ravi, PhD, assistant professor in the Department of Biomedical Informatics at the University of Colorado School of Medicine, didn’t intend to challenge the status quo when she began her career in data science. But after several years of working diligently on her research in computational biology as a graduate student at Virginia Tech, as a postdoc at Rutgers Biomedical and Health Sciences, and then as an independent researcher/faculty member at Michigan State University (MSU), she began to see a pattern emerge, particularly on the conference circuit.


Author Toni Lapp | Publish Date November 11, 2022
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Research    COVID-19    Faculty    Public Health

How a COVID-19 Mortality Prediction Model Created by CU Data Scientists Could Provide Insights for the Next Pandemic

Overflowing intensive care units. A shortage of personal protective equipment. A scramble for hospital beds and ventilators. Health care workers pushed to the brink. The COVID-19 pandemic laid bare many well-documented vulnerabilities of health care systems. The need for accurate and early clinical assessment of severity related to COVID-19 was vital to developing crisis standards of care to meet the growing pandemic. These standards of care are informed by mortality prediction models, which assess the risk of imminent death in patients.


Author Toni Lapp | Publish Date September 22, 2022
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Press Releases   

CU Anschutz Researchers Part of National Effort to Rapidly Boost AI in Medical Research

The National Institutes of Health will invest $130 million over four years, pending the availability of funds, to accelerate the widespread use of artificial intelligence (AI) by the biomedical and behavioral research communities.


Author Kelsea Pieters | Publish Date September 13, 2022
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Research   

What Is Artificial Intelligence in Healthcare?

Casey Greene, PhD, chair of the University of Colorado School of Medicine’s  Department of Biomedical Informatics, is working toward a future of “serendipity” in healthcare – using artificial intelligence (AI) to help doctors receive the right information at the right time to make the best decision for a patient. 


Author Matthew Hastings | Publish Date September 12, 2022
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COVID-19   

Data scientists in the spotlight

Melissa Haendel, PhD, professor in the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine, and her team of data scientists have been working at a lightning-fast pace for two years, unlocking some of the mysteries of long COVID. Not only have they been instrumental in the development of the largest national, publicly available HIPAA-limited dataset in U.S. history – the National COVID Cohort Collaborative (N3C) – but their research using the data is making headlines and getting the attention of the White House.


Author Wendy Meyer | Publish Date July 20, 2022
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Research    Press Releases    Education    Clinical Research    CU Medicine Today   

Department of Biomedical Informatics Launches to Advance Patient Care Using Data-Driven Discovery

Connecting basic science and medicine with clinical and translational scientists, the University of Colorado School of Medicine is introducing the Department of Biomedical Informatics (DBMI) to enhance clinical care through integrated computational technology, laboratory investigations, and artificial intelligence (AI).


Author Rachel Wittel | Publish Date July 06, 2022
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Innovation    Press Releases    Health Sciences   

Jayashree Kalpathy-Cramer, PhD, Named Chief of Artificial Medical Intelligence in Ophthalmology

Jayashree Kalpathy-Cramer, PhD, has been named chief of the new Division of Artificial Medical Intelligence in Ophthalmology at the University of Colorado (CU) School of Medicine. In her new role, Kalpathy-Cramer will translate novel artificial intelligence (AI) methods into effective patient care practices at the Sue Anschutz-Rodgers Eye Center.


Author Rachel Wittel | Publish Date March 17, 2022
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Press Releases    COVID-19   

Nationwide study of 'Long COVID' to launch at University of Colorado Anschutz Medical Campus

The National Institutes of Health (NIH) has invested nearly $470 million to build a national study population of diverse research volunteers and support large-scale studies on the long-term effects of COVID-19. The Colorado Clinical and Translational Sciences Institute (CCTSI) is playing a major role in the initiative called REsearching COVID to Enhance Recovery or RECOVER.


Author Wendy Meyer | Publish Date February 07, 2022
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Research    Press Releases   

Melissa A. Haendel joins CU Anschutz as Chief Research Informatics Officer

Melissa A. Haendel, PhD, has been named Chief Research Informatics Officer (CRIO) for the University of Colorado Anschutz Medical Campus, a newly created position responsible for transforming the campus use of information and information systems to accelerate biomedical discoveries, streamline health system operations, and continuously improve patient care. 


Author Mark Couch | Publish Date March 04, 2021
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Press Releases    Community   

Casey Greene Named Director of New Center for Health Artificial Intelligence

Casey Greene, PhD, has been named director of the new Center for Health Artificial Intelligence at the University of Colorado School of Medicine, where he will lead the creation of a center building communities that use sophisticated data analysis methods to advance research and improve clinical practice on the Anschutz Medical Campus.


Author Mark Couch | Publish Date October 20, 2020
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Innovation   

AI Offers Real-World Benefits to Healthcare

In contrast to the science fiction portrayal of evil computers plotting to overthrow humankind, artificial intelligence (AI) in fact seems poised to help improve human health in a multitude of ways, including flagging suspicious moles for dermatologist follow-up, monitoring blood volume in military field personnel and tracking flu outbreaks via Twitter.


Author Guest Contributor | Publish Date September 03, 2019
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Education   

How will artificial intelligence affect health care?

The explosion of big data promises potential breakthroughs in disease treatments, but, just as in the development of new drugs, scientists and clinicians must exercise caution in how they apply algorithms and other technologies, according to a CU Anschutz panel of experts.


Author Chris Casey | Publish Date February 21, 2019
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Campus Life   

390,000 square feet of possibilities

Campus and The Anschutz Foundation leaders, shovels in hand, on Wednesday turned ground on which the University of Colorado Anschutz Medical Campus takes another bold step toward revolutionizing health care for the region and the world.


Author Chris Casey | Publish Date January 31, 2019
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Department of Biomedical Informatics In the News

GenomeWeb

Building off ChatGPT Popularity, Generative AI Starts Finding its Place in Genome Informatics

news outletGenomeWeb
Publish DateSeptember 22, 2023

Shawn O’Neil, a data engineer at the Translational and Integrative Sciences Lab (TISLab) at the University of Colorado School of Medicine and training coordinator with the US National Institutes of Health’s National COVID Cohort Collaborative, recently joined the Monarch Initiative, an open-source bioinformatics platform for matching phenotypes to genotypes.

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National Institutes of Health (NIH)

Can Metformin Treat COVID-19 and Prevent Long COVID? NCATS and Partners Pursue Answers

news outletNational Institutes of Health (NIH)
Publish DateSeptember 18, 2023

The NCATS National COVID Cohort Collaborative (N3C), which includes DBMI faculty, powered two large studies that reinforced a potential link between metformin and less-severe COVID-19 outcomes. One study of EHRs from more than 6,600 adults found that those with type 2 diabetes who were taking metformin before developing COVID-19 were less likely to be hospitalized, need mechanical ventilation or die. A second study of people with either prediabetes or polycystic ovary syndrome (a condition commonly treated with metformin) showed that metformin use was linked to less severe COVID-19.

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KFF Health News

As More Patients Email Doctors, Health Systems Start Charging Fees

news outletKFF Health News
Publish DateSeptember 14, 2023

“We see physicians working two to four hours every evening on their patient emails after their shift is over, and that’s not sustainable,” says CT Lin, DBMI secondary faculty member and chief medical information officer at University of Colorado Health, which has not yet adopted billing for email visits. “But we worry that patients with complex disease will stop messaging us entirely because of this copay risk.”

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Nature

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms

news outletNature
Publish DateSeptember 13, 2023

Transcriptome-wide association studies have helped uncover the role of individual genes in disease-relevant mechanisms, explain researchers from the CU Department of Biomedical Informatics. However, modern models of the architecture of complex traits predict that gene-gene interactions play a crucial role in disease origin and progression. Researchers introduce PhenoPLIER, a computational approach that maps gene-trait associations and pharmacological perturbation data into a common latent representation for a joint analysis and observe that diseases are significantly associated with gene modules expressed in relevant cell types, and our approach is accurate in predicting known drug-disease pairs and inferring mechanisms of action.

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