A cancer cell is like a racecar, speeding through the process of cellular replication. But it has to stop at the G2M cell cycle checkpoint, where a race inspector called Wee1 checks it over for damage – cells with intact DNA can continue, while cells with damaged DNA have to stick around for repairs. The wait is worth it – there are curves ahead, and beyond the G2M checkpoint, cells with damaged DNA explode against the wall of “mitotic catastrophe.” But the thing is, we want cancer cells to explode; we would rather they speed through the G2M checkpoint without a Wee1 inspection and hit the wall of mitotic catastrophe.
Cancer Center | 
April 01, 2019
Cancer Health
