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CU Cancer Center News and Stories


Cancer    Adavosertib

Adavosertib speeds cancer cells into the wall of mitotic catastrophe

A cancer cell is like a racecar, speeding through the process of cellular replication. But it has to stop at the G2M cell cycle checkpoint, where a race inspector called Wee1 checks it over for damage – cells with intact DNA can continue, while cells with damaged DNA have to stick around for repairs. The wait is worth it – there are curves ahead, and beyond the G2M checkpoint, cells with damaged DNA explode against the wall of “mitotic catastrophe.” But the thing is, we want cancer cells to explode; we would rather they speed through the G2M checkpoint without a Wee1 inspection and hit the wall of mitotic catastrophe.

Author Cancer Center | Publish Date April 01, 2019
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