Recent advances in immunotherapy have allowed doctors at the University of Colorado Cancer Center to more effectively treat melanomas that spread to other parts of the body. Immunotherapy drugs such as checkpoint inhibitors, which are commonly used to treat melanomas, work to strengthen a patient’s immune system so that it can prevent a tumor from “turning off” the ability of the immune system to fight it.

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A crucial challenge in cancer research is figuring out how to make immunotherapies more effective, channeling, and selectively guiding the body’s own immune responses in targeting and killing tumors.

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Breast cancer patients whose cancer spreads to the brain may soon have new treatment options, thanks to research led by CU Cancer Center member Diana Cittelly, PhD.

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University of Colorado Cancer Center member M. Eric Kohler, MD, PhD, was awarded a three-year, $270,650 Young Investigator Grant from CureSearch for Children’s Cancer, in partnership with the SebastianStrong Foundation, to develop a new treatment approach for acute myeloid leukemia (AML), a rare blood cancer in children.

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Comedian and former “Saturday Night Live” cast member Norm MacDonald died Tuesday, after what his brother, Neil MacDonald, described as a nine-year battle with acute leukemia. Norm MacDonald, known for his intelligence and sarcastic wit, was 61.

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Looking to understand why some brain tumors with a specific mutation can start to reject drugs commonly used to treat them, CU Cancer Center member Jean Mulcahy Levy, MD, led researchers from institutions around the country — including several from the University of Colorado School of Medicine — to study samples of brain tumors before and after being treated with the drug.

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Evan Conant was one of the lucky ones. His stage I colon cancer was caught early, during a routine colonoscopy, and doctors at the University of Colorado Cancer Center were able to perform a surgery to remove the tumors entirely.

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One of the most impactful advancements during the past decade in treating ovarian cancer is the use of PARP inhibitors (short for poly adenosine diphosphate-ribose polymerase). PARP inhibitors are a type of cancer drug that blocks the PARP enzyme from helping to repair DNA damage in cancer cells.

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When Dara Aisner, MD, PhD, an associate professor in the Department of Pathology at the University of Colorado School of Medicine, was approached by a colleague at another university about splitting the cost of a bulk purchase of new clinical testing products, she initially declined. Although it would be a valuable resource — and might even save her lab money in the long-term — the short-term cost was prohibitive.

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The diagnosis came as a shock. Although, looking back, Bill Mordecai says it shouldn’t have been. 

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After suffering from painful bouts of pancreatitis for more than a decade, Christina Gonzalez felt resigned to a seemingly endless cycle of procedures.

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The doctors she saw initially didn’t seem too concerned, but 22-year-old Ella Neal knew something was seriously wrong. A persistent, unusual abdominal pain was keeping her up at night and distracting her from her studies at the University of Colorado Boulder.

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David Kooyman transferred his care to University of Colorado Cancer Center member and associate professor of thoracic oncology, Tejas Patil, MD, to be part of a clinical trial to help with his rare lung cancer gene fusion.

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Richard Schulick, MD, MBA, director of the University of Colorado Cancer Center, becomes close with all of his patients, but he has a special bond with Gerry Turner, one of Schulick’s surgical patients for pancreatic cancer.

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Comedian Kathy Griffin’s recently announced lung cancer diagnosis came early and arose from a non-related health screening. A lucky catch, and an understandable path to detection for a person who never smoked.

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Despite the growing threat of the Delta variant, many Americans who have been vaccinated against COVID-19 are living life much as they did pre-pandemic — traveling, shopping, going out to eat, and forgoing masks in many situations.

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The most important factor predicting the survival of pancreatic cancer patients is whether the cancer can be surgically removed (whether the cancer is “resectable”). The answer isn’t always clear.

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Each year, Denver-area magazine 5280 publishes its list of top doctors. On this year’s list, which came out last week, CU School of Medicine faculty members continue to be ranked among the best. We are proud to congratulate the 138 CU School of Medicine faculty members honored with the title Top Doctor.

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Comedian Kathy Griffin, 60, shared the news with the world Monday via Twitter: She was about to undergo surgery for stage I lung cancer.

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The Colorado Cancer Coalition launched the 2021­–2025 Colorado State Cancer Plan in the town of Cheyenne Wells on July 23, in concert with the Communities That Care Community Action Plan with Cheyenne County Local Public Health. More than 40 Cheyenne County residents joined in person, and nearly 100 more joined virtually. One of the Colorado Cancer Coalition's main priorities is to focus on increasing capacity and screening rates in rural and frontier counties. Over the past year, the coalition has focused on Cheyenne County, which has the second highest age-adjusted incidence rate of cancer in Colorado.

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Though the two main histological types of breast cancer — lobular and ductal — are treated with the same hormonal therapies, women with lobular breast cancer often have recurrence or metastasis of the disease several years after their initial treatment.

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When you ask a classroom full of middle schoolers what they want to be when they grow up, you’re likely to get a range of answers, from “pro athletes” and “astronauts” to “musicians” and “movie stars.”

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The early days of the COVID-19 pandemic were an adjustment period for medical professionals across the board, but they brought up particular challenges for the Cancer Clinical Trial Office (CCTO) at the University of Colorado Cancer Center. A number of procedures that used to take place in person or in the office — collecting signatures from patients and doctors, delivering medications, submitting data to trial sponsors — suddenly had to be done in a whole new way.

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A study led by D. Ross Camidge, MD, PhD, director of thoracic oncology at the University of Colorado School of Medicine and CU Cancer Center member, has helped to define MET amplification as a rare but potentially actionable driver for non-small cell lung cancer (NSCLC).

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It’s difficult enough when a loved one is diagnosed with cancer, but employed spouses of those who receive the diagnosis also are confronted with an array of practical problems. It’s now up to them to untangle issues around medical leave, health insurance, caregiving benefits, and more.

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Dmitri Simberg, PhD, an associate professor in the Department of Pharmaceutical Sciences in the Skaggs School of Pharmacy and a CU Cancer Center member, has released the results of a new study of the effectiveness of different types of fluorescent labels used to monitor the accumulation of liposomes in tumors.

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As director of the Animal Imaging Shared Resource at the University of Colorado Cancer Center, Natalie Serkova, PhD, has played an integral part in many groundbreaking projects on the Anschutz Medical Campus.

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Nearly 30 researchers and physicians from the University of Colorado Cancer Center shared the results of their work at a June 15 online event titled “Collaborating to Conquer Cancer: A virtual conversation benefiting the CU Cancer Center.”

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All cells use the process of metabolism to turn nutrients into energy — including cancer cells. Metabolism is a fundamental function whose role in cancer is being explored by researchers across the CU Cancer Center.

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Two recent collaborative publications by CU Cancer Center members provide insights into how chronic inflammation can serve as a key factor in the development of leukemia and other blood cancers.

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A discovery by CU Cancer Center member Traci Lyons, PhD, is providing new hope for women with metastatic breast cancer.

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Since a chance discovery by U.S. Army scientists studying mustard gas during World War II, chemotherapy has added countless years to cancer patients’ lives around the world.

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Though people most often think of melanoma as affecting the skin, the cancer can occur anywhere in the body where pigment-producing melanocyte cells are found. That includes mucous membranes in the head, neck, eyes, respiratory tract, and genitourinary region.

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The University of Colorado Cancer Center is at it again this year, gathering a group of 12 employees or members who will rappel 44 stories to raise money and awareness for Colorado-based cancer research. The Over the Edge event is put on by the Cancer League of Colorado (CLC).

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U.S. News and World Report released its 2021–22 Best Children’s Hospitals rankings this week. Children’s Hospital Colorado ranked number 6 nationally and placed seven pediatric specialties in the top 10, including a number-one ranking for gastroenterology and gastrointestinal surgery. Children’s Colorado is affiliated with the University of Colorado School of Medicine. Together, the institutions are a national center for clinical care and medical research.

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Patients’ rights advocates scored a major victory in April, when a provision went into effect that allows patients immediate access to all information in their medical records, including physician notes and test results. The change is part of the 21st Century Cures Act, which was passed by Congress in 2016 and continues to be updated.

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The recent decrease in the age recommendation for colorectal cancer screening came as no surprise to Chris Lieu, MD, associate director of clinical research at the CU Cancer Center. Like many cancer doctors around the country, Lieu has seen an alarming increase in recent years of cases of colorectal cancer in patients younger than 50.

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A pilot study of childhood leukemia patients living near Colorado’s oil and gas drilling sites recently led to an American Cancer Society (ACS) grant award for CU Cancer Center member Lisa McKenzie PhD, MPH.  

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Research and treatment of head and neck cancers at the University of Colorado Cancer Center reached a new level this month with a highly competitive Specialized Programs of Research Excellence (SPORE) grant from the National Cancer Institute (NCI). The SPORE was approved by NCI Scientific Program leadership for FY2021 funding; the projected starting date is July 1

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The COVID-19 vaccines are beginning to significantly slow the spread of the virus, but the Pfizer and Moderna and vaccines are having an unforeseen consequence for breast cancer doctors. The vaccines often cause swelling in the armpit or underarm that can mimic the lumps associated with breast cancer, causing some women undue concern.

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National Cancer Survivors Day, June 6, 2021, is a day to recognize cancer survivors, bring attention to the ongoing challenges cancer survivors face, and celebrate life. 

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Three members of the University of Colorado Cancer Center and a longstanding supporter of the campus are part of a group of more than 200 researchers nationwide who were recognized in April with the Team Science Award from the American Association for Cancer Research (AACR).

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Looking for better ways to treat patients with esophageal cancer, University of Colorado Cancer Center member Martin McCarter, MD, is investigating whether a new treatment sequence will result in better outcomes.

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One of the most difficult nights of Hank Baskett Sr.’s life was the night he told his wife he had been diagnosed with lung cancer.

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In a move that has the potential to save thousands of lives, the U.S. Preventive Services Task Force (USPSTF) this week lowered the recommended screening age for colorectal cancer from 50 to 45 for asymptomatic patients with no family history of colorectal cancer. Considered the leading source of medical guidance in the U.S., the USPSTF is an independent, volunteer organization made up of national experts in internal medicine, family medicine, pediatrics, OB/GYN, nursing, behavioral health, and more.

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After seeing the tragic COVID-19 crisis unfolding in India, Saketh Guntupalli, MD, associate professor of gynecologic oncology in the University of Colorado School of Medicine and member of the University of Colorado Cancer Center, decided to do something about it.

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Long before RNA and mRNA became important parts of the COVID-19 vaccine conversation, researchers at the University of Colorado School of Medicine were studying how RNA biology can improve diagnostics and therapeutics for a range of diseases.

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Siri Lindley couldn’t swim. She had never learned how and the idea of competing in a triathlon seemed completely out of the question.

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It feels odd to use the phrase “perfect timing” when talking about a cancer diagnosis, but that’s exactly how Tonya Quinn describes her experience being diagnosed with breast cancer two years ago.  

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May is National Cancer Research Month, during this time we aim to raise awareness of the high-quality, innovative cancer research happening at the University of Colorado Cancer Center. This research continues to help the more than 16.9 million people in the United States who are living with, through, and beyond their cancer diagnoses. 

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When Manali Kamdar, MD, joined the University of Colorado School of Medicine’s Division of Hematology as clinical director of lymphoma services in January 2015, she was fresh off her third fellowship (a bone marrow transplant and lymphoma fellowship at Stanford) and ready for a new challenge.  

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Bringing more than two decades of experience in the fields of population health and cancer prevention and control, Linda Cook, PhD, will join the University of Colorado Cancer Center in July as associate director of population sciences.

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Two members of the University of Colorado Cancer Center have received prestigious Idea Awards from the U.S. Department of Defense’s Peer Reviewed Cancer Research Program (PRCRP).

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Not all cancerous tumors are created equal. Some tumors, known as “hot” tumors, show signs of inflammation, which means they are infiltrated with T cells working to fight the cancer. Those tumors are easier to treat, as immunotherapy drugs can then amp up the immune response.

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Thirty days of radiation treatments — five days a week, with Saturdays and Sundays off — are difficult for even the toughest of adults. But for a child, they’re even harder to bear. They involve fasting, waking up early, and lying in a dark room alone, without even your parents there for support.

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Two University of Colorado Cancer Center researchers have received a five-year R01 Award for $497,893 per year from the National Institutes of Health (NIH) to study a potential new drug treatment for salivary gland cancer. The award is part of an inter-campus collaboration between Antonio Jimeno, MD, PhD, co-leader of the Developmental Therapeutics Program, and Tin Tin Su, PhD, co-leader of the Molecular and Cellular Oncology Program.

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Over the past few years, Camille Stewart, MD, assistant professor of surgery in the Division of Surgical Oncology, has conducted research for the Society of Surgical Oncology (SSO) to examine unconscious bias within the organization. In her studies, Stewart examines unconscious bias and microaggressions by focusing on the subtle differences in introductions of speakers at professional meetings and conferences.

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Pablo Garcia started to worry when he began experiencing unusual stomach symptoms. He worried even more when his doctor at the Salud Family Health Center in Longmont, Colorado, ordered a colonoscopy to check for signs of colon cancer. Pablo was unfamiliar with the procedure, the preparation, and the hospital where the test was to take place. 

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A new study co-authored by University of Colorado Cancer Center researcher Srinivas Ramachandran, PhD, shows how DNA segments known as enhancers function in cells.

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New research from CU Cancer Center member Scott Cramer, PhD, and his colleagues could help in the treatment of men with certain aggressive types of prostate cancer.

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Although rare, kidney cancer is the third most common type of solid tumor affecting children. Thankfully, pediatric kidney tumors are generally treatable and most have high cure rates. Treatment outcomes depend on several factors including age, tumor type, staging, genetics, the overall health of the patient, and the risk of treatment side effects.  

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A new phase 3 randomized clinical trial overseen by CU Cancer Center member Chad Rusthoven, MD, and Vinai Gondi, MD, from Northwestern University, is testing whether a new treatment approach could result in improved outcomes for patients with small cell lung cancer (SCLC) that has spread to the brain. 

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Cancer doctors may soon have a new tool for treating melanoma and other types of cancer, thanks to work being done by researchers at the University of Colorado Cancer Center.

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A team of University of Colorado School of Medicine researchers recently published a paper offering new insight into the role that oxygen deprivation, or hypoxia, plays in cancer development. CU Cancer Center member Joaquin Espinosa, PhD, is the senior researcher on the paper, which he hopes will help lead to more targeted treatments for cancer. 

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M. Eric Kohler’s commitment to both cancer research — particularly CAR T-cell therapy — and clinical care make him a double threat when it comes to battling pediatric blood cancer.   

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Though breast cancer patients are now living longer than ever before, treatments for the disease can have wide-ranging effects on their long-term quality of life. Physical, social, and sexual wellbeing all can be impacted by radiation, chemotherapy, surgery, antiendocrine therapy and other challenges that go along with a breast cancer battle.

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Sabrina L. Spencer, PhD, is a CU Boulder researcher and a CU Cancer Center member. Spencer recently won two awards: the Damon Runyon-Rachleff Innovation Award (from the Damon Runyon Cancer Research Foundation) and the Emerging Leader Award (from The Mark Foundation for Cancer Research). The preliminary research she used to apply for the grants, "Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling," was published in Nature Communications on March 19, 2021.

We spoke to Spencer about the awards and how she plans to use them to further her research.

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Three University of Colorado Cancer Center researchers are part of a team that recently published a paper offering new insight into how the immune system relates to cancer. Quentin Vicens, PhD, Jeffrey Kieft, PhD, and Beat Vögeli, PhD, are authors on the paper, which looks at how an enzyme called ADAR1 operates in pathways associated with cancer.

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A multiyear grant totaling $500,000 is aimed at making the University of Colorado Cancer Center even better at providing multidisciplinary care for patients with pancreatic cancer.

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Ashton Villars has always been a problem solver. As a competitive athlete in basketball, waterskiing, and tennis and an actual rocket scientist, Villars has tackled every challenge in life head on — including his prostate cancer diagnosis. Now, he’s bringing that same problem-solving spirit to supporting cancer research. 

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Three projects from University of Colorado Cancer Center researchers have received grants from the Denver-based Michele Plachy-Rubin Fund for Pilot Grants in Brain Cancer Research. Receiving $40,000 each to fund their work around brain cancer are Sujatha Venkataraman, PhD; and the teams of Philip Reigan, PhD, and Michael Graner, PhD; and Natalie Serkova, PhD, and Nicholas Foreman, MD, MBChB.

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For more than a year, a working group at the University of Colorado Cancer Center has been studying the many ways the aging process impacts cancer — including incidence, progression, and prognosis of the disease, therapeutic options and outcomes, and the psychosocial aspects of living with cancer.

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The Denver chapter of Golfers Against Cancer this week named University of Colorado (CU) Cancer Center researchers Matthew Sikora, PhD, Jamie Studts, PhD, and Jenna Sopfe, MD, as the beneficiaries of three $50,000 grants for cancer research and clinical trials.

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CU Cancer Center member Neil Box, PhD, is on a quest to decrease the deadly effects of melanoma.

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At the University of Colorado (CU) Cancer Center, we use awareness months and days to highlight and honor our patients – both past and present – that have fought these cancers, as well as educate about warning signs, new treatments, clinical trials, prevention methods, and support options.

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Actor Dustin Diamond, best known for playing the nerdy character Screech on teen sitcom “Saved By the Bell,” died Monday at age 44. Diamond died just weeks after being diagnosed with stage 4 small cell carcinoma, a type of cancer that commonly occurs in the lungs but can also originate in the prostate or gastrointestinal tract.

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For the past 20 years, the Union for International Cancer Control has designated February 4 as World Cancer Day — a day to raise awareness, improve education, and catalyze personal, collective, and government action around the deadly disease. The organization hopes to reduce the number of premature deaths from cancer and noncommunicable diseases by one-third by 2030.

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Breast cancer is harmful enough on its own, but when cancer cells start to metastasize — or spread into the body from their original location — the disease becomes even more fatal and difficult to treat.

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January is Cervical Cancer Awareness Month, and CU Cancer Center member Lindsay Brubaker, MD, wants everyone to be aware of the relationship between cervical cancer and the human papillomavirus (HPV), a sexually-transmitted disease that causes the vast majority of cervical cancers. The current HPV vaccine protects against seven predominant strains of the virus that cause cancer, as well as the two that cause genital warts.

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New research from CU Cancer Center member Jing Hong Wang, MD, PhD, and recent University of Colorado Immunology program graduate Rachel Woolaver, PhD, may help researchers develop more effective personalized immunotherapy for cancer patients.

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There’s never a good time for a cancer diagnosis, but it’s especially difficult in the middle of a pandemic, when concerns about safety compound the worry and anxiety that come along with hearing, “you have cancer.”

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A 13-year veteran of the National Cancer Institute (NCI) is coming to the University of Colorado Cancer Center to help lead efforts to develop and apply data science and artificial intelligence and methods to advance research and improve clinical practice.

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The global pandemic of 2020 has been a pivotal year for the health care industry. This year lead some CU Cancer Center members to shift their focus to learning more about COVID-19 while others continued their research on cancer. Whether the focus was on COVID-19 or Cancer this year showed how coming together as a community can make a difference. 

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COVID-19 is the most-talked-about health concern in 2020, but for many, it is not the deadliest disease. University of Colorado (CU) Cancer Center leadership is bringing attention to the fact that more people will die from cancer than COVID this year.

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Like most people, Arnette Schouten has been touched personally by cancer. One of her cousins is in hospice following a battle with melanoma; her sister-in-law had a long fight with breast cancer; and Arnette herself had early symptoms of ovarian cancer that were caught in time for effective treatment.

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Medical cannabis was legalized in Colorado in 2000, but 20 years later, Camille Stewart, MD, isn’t able to prescribe it to her patients. Nor is she able to dictate the dosage or frequency with which patients take the drug.

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The past year has illuminated the need for change. In addition to the toll it has taken on lives, health and livelihood, COVID-19 has shed light on health disparities and inequities facing our communities of color.

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Elissa Kolva, PhD, clinical psychiatrist and CU Cancer Center member, shares tips that might be helpful for caregivers during the COVID-19 pandemic.

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Until you or a loved one are facing treatment for a cancer diagnosis, you may not realize the cost associated with treatment and doctor visits. Unfortunately, the cost is continuing to rise as new treatments are discovered and patients are responsible for more of those costs, even if they have health insurance coverage.

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Craig Jordan, PhD, has spent more than 20 years developing better treatments for acute myeloid leukemia (AML), a rapidly progressing cancer of the blood and bone marrow that can spread to other parts of the body, including the lymph nodes, liver, spleen and central nervous system.

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The CU Cancer Center has launched five studies that are focused on addressing disparities in care and outcomes for Black and Hispanic communities in Colorado.

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Longtime “Jeopardy!” host Alex Trebek announced it to the world on March 6, 2019: Like 50,000 other Americans each year, he had been diagnosed with stage 4 pancreatic cancer.

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Thanks in large part to early work by investigators at the CU Cancer Center, patients with acute myeloid leukemia (AML) have a new treatment option that has fewer side effects and has been shown to increase longevity.

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Elissa Kolva, PhD, clinical psychiatrist and CU Cancer Center member, shares tips around self-care for a caregiver of a loved one with cancer.

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Melissa Turner had already survived two bouts of breast cancer, so the last thing she expected to hear in early 2018 after experiencing a series of mysterious symptoms was, “You’ve got lung cancer.”

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A new movie streaming on Disney+ is shining a spotlight on a rare type of bone cancer that occurs most often in children and young adults.

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If you live in or have visited Colorado, you most likely noticed that the state loves its outdoors. With 300 days of sunshine a year, many enjoy hiking, playing at a park or grabbing a craft brew on a patio. But with that love of sunshine comes an increased risk for skin cancer.

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In the 1860s, French physician Armand Trousseau noticed that patients with a certain form of abnormal blood clotting often went on to be diagnosed with pancreas or gastric cancers. Unfortunately, at age 66 he noticed these same symptoms in himself and died of gastric cancer only a few months later.

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In a 1983 concert video, guitar legend Eddie Van Halen abandons his pick as he sets the stage for his famous "Eruption" solo. After popping the pick into his mouth and tucking a cigarette into the top strings of his guitar, the well-loved musician’s fingers fly across his instrument’s neck, a trail of smoke rising from it with every wailing note.

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Although prostate cancer is treatable when found early, there are common fears that men share concerning prostate cancer.

“I hear from patients all the time stating they do not want to get tested and they do not want to know if they have prostate cancer. Due to the possible side effects associated with treatment,” says Paul Maroni, MD, associate professor in the Department of Surgery, Urology Division, program director of the Urologic Cancer Care Center and University of Colorado (CU) Cancer Center member.

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Studies have long reported that Black cancer patients have poorer outcomes than their white counterparts. But two University of Colorado Cancer Center researchers decided to investigate the data further and figure out why. What they found was that the outcome disparity was caused not by biology, but simply by differences in access to health care.

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A consortium of 17 cancer centers around the country have come together to better understand the consequences of the COVID-19 pandemic as it relates to delayed cancer detection, care and prevention.

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Growing up, Douglas “Bucky” Dilts was all too familiar with the dangers of cancer. “My mother ran a cancer tumor registry at St Joseph's Hospital in Atlanta, Georgia for over 25 years. She was always telling us about different types of cancer, so cancer was always at the forefront.”  

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By now, we’ve all heard about the importance of cancer screening. But for those with a detected cancer, a new article highlights that the removal of the malignancy might not be where you should stop in your health journey.

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From “No Hair Don’t Care” to “Keep Calm and Colorado On,” four friends facing two grim diagnoses used humor and grit in their battles against cancer. All four contend that, without their outlook and a little fate, their crusade might have had a different ending.

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After nearly four years of work, a group of researchers and clinicians from the University of Colorado (CU) published a paper this week in the Clinical Cancer Research that shares findings from research looking at how the composition of ovarian cancer tumors changes during chemotherapy and contributes to therapeutic response.

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Chadwick Boseman’s all-too-early death has cast the spotlight on a trend University of Colorado School of Medicine doctors have been heralding for nearly two decades. Colorectal cancer, the disease that took the acclaimed actor of “Black Panther” fame, no longer falls in the old-person’s disease bucket.

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Last month the American Cancer Society (ACS) released updated guidelines for cervical cancer screening. The most notable change in guidelines is the changes in the age to begin screening. Per the new guidelines, it is recommended that cervical cancer screening begin at age 25. Previously, the starting age for screening was 21.

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As survival rates of many common cancers have improved it is no surprise that conversations around fertility preservation have also increased. These advances in treatments are letting patients think about their future beyond cancer, and if that future includes children.

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A key component in treating newly diagnosed leukemia is genetic and molecular testing. With this knowledge, physicians can better determine which treatment options are best suited for patients based on genetic mutations, fusions and other biologic features. 

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Black and Hispanic children diagnosed with brain and central nervous system (CNS) cancers have worse outcomes than their white counterparts in the United States. The reasons behind this are unclear but may include socioeconomic factors and/or limited access to quality care. Now, researchers at the University of Colorado (CU) Cancer Center and Children’s Hospital Colorado on the Anschutz Medical Campus are collaborating to better understand these disparities, as well as develop ways to reduce the burden of disease in these populations.

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University of Colorado Cancer Center member and associate professor of Pathology Paul Jedlicka, MD, PhD, has received the St. Baldrick’s Research Grant with generous support from Marlee’s Smile. His research will focus on better understanding the mechanisms behind rhabdomyosarcoma, a common and aggressive cancer type in children. The goal of the research is to identify new approaches to interfering with disease progression.

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On July 23rd, Richard Schulick, MD, MBA, director of the University of Colorado (CU) Cancer Center, Cathy Bradley, PhD, deputy director of the CU Cancer Center, James DeGregori, PhD, deputy director of the CU Cancer Center, took part in a virtual panel that highlighted the impact of COVID-19 on cancer as well as the ways the CU Cancer Center is redefining cancer care. The panel was moderated by Don Elliman, Chancellor of the Anschutz Medical Campus.

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The American Cancer Society recently updated its recommendation from limiting alcohol to avoiding alcohol altogether to reduce cancer risk. Here, the University of Colorado Cancer Center discusses this update with Valaree Williams, MS, RD, CSO, CNSC, FAND, lead dietician from the Oncology Supportive Services at UCHealth.

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Prevent and Conquer Cancer. Together. At University of Colorado Cancer Center, that’s our vision. During COVID-19, that vision hasn’t changed and, in fact, may be more important now than ever before. 

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Cecilia Caino, PhD, has been researching cancer cell biology at University of Colorado Cancer Center since 2017. Cecilia earned her PhD in Cellular Biology from the University of Buenos Aires with her research component performed at the University of Pennsylvania, and completed a postdoctoral fellowship at The Wistar Institute. We spoke with Dr. Caino about her research on how cancer cells use energy and how their unique energy strategies could help cancer cells spread.

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In the midst of a global pandemic, it seems odd to be asking my 18-year-old neighbor about the dangers of vaping. However, keeping a safe six-foot distance away and wearing homemade masks, we’re able to hold a decent conversation across the front lawn. My question is simple: Is vaping dangerous? His answer: “I don’t know, but I think it is safer than smoking a cigarette.”

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“Have you ever had a dream when you wake up and everything is just kind of vibrating? It doesn’t make any sense but it kind of points the way?” asks Fort Collins artist and musician, Shelley Kerr.

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In July 2019, Emily McClintock Addlesperger was on vacation in Maine with her husband, Jason, when she felt sick and was airlifted to Portland with internal bleeding. A tumor on her ovary had burst. It was Monday. On Saturday, she passed away. Emily was 44 years old.

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University of Colorado Cancer Center member Ryan Weight, DO, MS, has always been passionate about caring for patients. However, in early April, in the middle of a global pandemic, the way he goes about patient care looks a little different.

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January 2020 was unseasonably warm and dry, so pleasant that students on the Anschutz Medical Campus ate lunch at picnic tables and scientists emerged confused and squinting from hibernation in the campus research buildings. One person who was not there was Deguang Kong, visiting graduate student in the lab of Heide Ford, PhD, University of Colorado (CU) Cancer Center Associate Director for Basic Research. With his PhD work wrapping up, Deguang had taken a quick leave to interview for jobs near his home…in Wuhan, China.

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Telemedicine is not a new concept. However, due to the coronavirus pandemic, it might not be something that many providers or patients are becoming familiar with. Recently, it was announced that over 200,000 virtual primary care and specialty visits have occurred since the start of the pandemic at UCHealth, where University of Colorado (CU) Cancer Center doctors provide care.

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While runs and galas that raise money for many different causes have been affected by COVID-19 there is one fundraising event that is made for social distancing, rappelling down a building. The Over the Edge event by the Cancer League of Colorado (CLC) is doing just that while raising money for Colorado based cancer research.

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Many patients diagnosed with COVID-19 have symptoms such as a persistent dry cough, shortness of breath, and in some cases, incredibly low oxygen levels in their blood. Additionally, many patients report having long-lasting side effects, for example decreased lung capacity, even after they recover from the virus.

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Originally posted on the University of Colorado (CU) Department of Psychiatry website. Tips from Joanna Arch, PhD, associate professor in the Department of Psychology and Neuroscience and CU Cancer Center member.

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Video Transcript:

Good morning, I’m Dr. Breelyn Wilky from the sarcoma program at the University of Colorado Cancer Center.

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In late 2019, two remarkable women were brought together by a shared experience that could only happen at the University of Colorado Anschutz Health & Wellness Center. Through their participation in the BFitBWell Program for cancer survivors, they found renewed strength and friendship.

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Nearly two thousand people living in Colorado will be diagnosed with head and neck cancer (HNC) in 2020. Generally, a very aggressive disease, head and neck cancer require expert care that is not widely available in community cancer clinics. However, patients that are not well-represented in clinical studies, especially Hispanic patients, are less likely to get care from centers that specialize in the disease, such as the University of Colorado Cancer Center.

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Lung cancer is the deadliest cancer in the United States. In Colorado more than 2,500 people will be diagnosed with the disease and more than 1,400 will die of it in 2020. While advances in lung cancer treatment have gifted many patients with more time, the benefit of these treatments is limited by the racial and socioeconomic status of some patients in Colorado. A new study at the University of Colorado Cancer Center focuses on reducing disparities in lung cancer patients with diverse backgrounds.

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While many cancer types have added new treatments including genetically targeted drugs and immunotherapies, treatment for the rare types of cancer known as sarcomas have remained largely the same for about two decades. Now, two grants to University of Colorado Cancer Center researchers from the Sarcoma Foundation of America hope to change this.

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U.S. News and World Report (USNWR) released its 2020-21 Best Children’s Hospitals rankings this week. In the category of best hospitals for pediatric cancer, Children’s Hospital Colorado was ranked ninth in the country. Pediatric cancer services are provided by University of Colorado (CU) School of Medicine faculty who many are members of the CU Cancer Center.

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University of Colorado (CU) researcher Srinivas Ramachandran, PhD, was named one of the five 2020 Pew-Stewart Scholars. These researchers are selected to spearhead innovations in cancer research.

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University of Colorado radiation oncologist Chad Rusthoven, MD, was recently awarded the prestigious Dr. Charles A. Coltman Jr. research fellowship award from the Hope Foundation for Cancer Research. The award provides two years of salary support to engage early career investigators from Southwest Oncology Group (SWOG) affiliated institutions in clinical trial research.

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When a blood cancer patient needs a bone marrow transplant, there are four common donor sources: A matched related donor (sibling), a matched unrelated donor (from a donor database), a half-matched donor, or umbilical cord blood. Of course, there are plusses and minuses to each approach, but consensus has generally ranked a matched sibling first, followed by a matched unrelated donor, with cord blood and half-matched donors reserved for patients without either of the first two options. Now a University of Colorado Cancer Center study based on a decade of research and treatment may reshuffle this list. In fact, the comparison of 190 patients receiving cord-blood transplants with 123 patients receiving transplants from the “gold standard” of matched sibling donors showed no difference in survival outcomes between these two approaches, with significantly fewer complications due to chronic graft-versus-host disease in patients receiving transplants from cord blood.

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Clinical psychologist Emily Cox-Martin, Ph.D., discusses National Cancer Survivors Awareness Day and offers tips and tricks for maintaining and improving the mental health of cancer survivors.

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The international First-line Radiosurgery for Small-Cell Lung Cancer (FIRE-SCLC) analysis led by University of Colorado Cancer Center researchers and published today in JAMA Oncology details clinical outcomes for 710 patients with brain metastases from small cell lung cancer treated with first-line stereotactic radiosurgery (SRS), without prior treatment with whole-brain radiation (WBRT) or prophylactic cranial irradiation (PCI).

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Results of the phase III Inter-B-NHL-ritux 2010 clinical trial reported today in the New England Journal of Medicine show 95 percent three-year survival for pediatric patients with advanced B-cell non-Hodgkin lymphoma treated with the addition of anti-cancer immunotherapy rituximab to standard chemotherapy. The trial represents a major international collaboration between the European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the Children’s Oncology Group (COG), and was led in the United States by Thomas Gross, MD, PhD, University of Colorado Cancer Center investigator and pediatric oncologist at Children’s Hospital Colorado, and in Europe by Véronique Minard-Colin, MD and Catherine Patte, MD, both pediatric oncologists at the Gustave Roussy Department of Child and Adolescent Oncology in Paris, France. The addition of rituximab decreased treatment failures by 70 percent resulting in a 10 percent increase in the three-year survival rate seen with chemotherapy alone (LMB protocol).

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From Barbara Wenger, breast cancer survivor:

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In mid-March, the University of Colorado Cancer Center Cell Technologies Shared Resource shut down along with almost all the other labs and technologies on the Anschutz Medical Campus. Then shared resource director, Steve Anderson, PhD, got an email from a colleague asking if the facility could make COVID-19 proteins. They could: The shared resource has been making proteins for over 15 years.

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In 1844, multiple myeloma was first treated with a rhubarb pill and an infusion of orange peel. Since then, more than 15 drugs have earned FDA approval to treat multiple myeloma and with so many options, a major question has become what cocktail and sequence is best?

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One of the few labs on the Anschutz Medical Campus to remain mostly open during the COVID-19 shutdown is the University of Colorado Cancer Center Animal Imaging Shared Resource (AISR).

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“For Christmas, we took a family photo with all the grandkids,” says Sam’s wife, Janet. She went on to explain, “The kids wanted to take this photo because they thought Sam would not be here next Christmas.”

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You’ve heard of the Human Genome Project. Now the University of Colorado Cancer Center Human Immune Monitoring Shared Resource (HIMSR) is partnering with the Cancer Center Tissue Biobanking and Histology Shared Resource to store COVID-19 samples for individual research efforts and for a major project known as the COVID-ome. 

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During the COVID-19 pandemic patients with cancer may be experiencing mental health challenges such as increased anxiety or depression. The psycho-oncology team at the CU Cancer Center is providing tips that can help during these difficult times. 

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One of the major complications of severe COVID-19 is blood clots in the lungs – a pulmonary embolism that can block lung function leading to death. In fact, these blockages are similar to those from chronic heart disease, stroke, and even traumatic injuries like a car crash or gunshot wound. In these non-COVID-19 conditions, doctors use drugs to break up and dissolve the clotted blood. Now a team led by Colorado trauma surgeon Gene Moore, MD, is testing a similar approach against the dangerous blood clots associated with COVID-19.

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We all know that in the spring or before going on a beach vacation, it’s important to get a solid tan so that we don’t get burned. After all, it’s sun burns and not sun tans that cause skin cancer, right? Not so fast, says Neil Box, PhD, University of Colorado Cancer Center investigator and president of the Colorado Melanoma Foundation.

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French and Australian studies suggest the anti-malarial drug chloroquine could be effective against COVID-19. Promising early results now lead the U.S. Food and Drug Administration to fast-track its own tests, and have spurred the drug’s maker, Bayer, to offer the drug free for treatment. Earlier today, President Trump (among others) touted chloroquine as a ready-to-use treatment for the disease.

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We should all be doing our best to keep from catching COVID-19, if not for ourselves and our loved ones, then to avoid passing the disease to people in high-risk populations – like cancer patients taking chemotherapy, which can lower white blood cell counts and undercut the effectiveness of remaining white blood cells, leaving these patients immunocompromised and less able to fight infections like COVID-19.

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Steve Becker always looks forward to Veterans Day. He and his father, Don, both did hitches in the Navy, so it’s a special day they set aside to hang out and reflect on their service to the nation.

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Phase III clinical trial results reported today in the New England Journal of Medicine and presented concurrently at the San Antonio Breast Cancer Symposium (SABCS) 2019 show the combination of the investigational drug tucatinib with standard of care treatment including the drugs trastuzumab and capecitabine nearly tripled one-year progression-free survival (33 percent vs. 12 percent), and nearly doubled the two-year overall survivor (45 percent vs. 27 percent) in women with HER2+ metastatic breast cancer. The international, multi-center trial, named HER2CLIMB (NCT02614794), builds on early development and clinical trials involving the  University of Colorado Cancer Center.

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Patients aren’t the only ones affected by cancer. Often alongside patients are family caregivers who struggle to keep their own lives on track while supporting their loved one’s treatment and recovery. It’s not easy. For example, a study showed that stress increases a family caregiver’s chance of death by 63 percent over four years. Now a nearly $4M grant from the National Cancer Institute to researchers at University of Colorado Cancer Center seeks to lessen the impacts of stress specifically on cancer caregivers who are also employed. The project hopes to help caregivers manage the demands of their jobs and their lives, while also meeting the day-to-day needs of their loved one with cancer.

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The growth of some breast cancers is driven by hormones like estrogen and progesterone. Other breast cancers are driven by changes in the gene HER2. Still some cancers are driven by both – and breast cancers whose growth can be controlled by hormonal receptors and HER2 can be especially tricky to treat. A University of Colorado Cancer Center phase 1b study presented at the American Society for Clinical Oncology (ASCO) Annual Meeting 2019 offers an attractive alternative to the chemotherapy that is often used with these patients: the three-drug cocktail of targeted treatments – tucatinib, palbociclib and letrozole – was overall well-tolerated and showed preliminary evidence of promising anti-cancer activity. Results support the continued development of the combination in an ongoing phase 2 clinical trial.

“I see this as a promising chemotherapy-free combination for patients who have been without good options, especially for those whose disease has spread to the brain,” says Elena Shagisultanova, MD, PhD, investigator at CU Cancer Center and the trial’s principal investigator.

Tucatinib is a targeted HER2 inhibitor; palbociclib stops cancer cells from rushing through the cell cycle required for fast proliferation; and the anti-hormonal drug letrozole restricts the ability of cancers to drive growth using estrogens. Previous work has shown that palbociclib and letrozole combine to kill more cancer cells than letrozole alone. And lab work by Shagisultanova and her mentor Virginia Borges, MD, at CU Cancer Center led them to believe that tucatinib should be a potent addition to this combination.

Results of the current trial show that the theory holds up in humans: of 20 patients enrolled on the study since November 2018, 14 remained on study as of 1/4/2019, five of which had been on the study more than 6 months. The goal of the phase 1b study was to explore the safety of this combination, with no patients experiencing side effects that required study withdrawal.

“All these patients have metastatic breast cancer and up to five different treatments before trying this trial. Also, 45 percent have brain metastases. In this population, our results look promising,” Shagisultanova says.

A phase 2 trial further exploring the combination is offered at CU Cancer Center, University of Arizona, Northwestern University, New Mexico Cancer Care Alliance, Stony Brook University, and University of Texas Health Science Center San Antonio.

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Karen Possehl was diagnosed with cancer in November 2016. At the Mayo Clinic in Arizona, her doctor told her that the type of cancer she had was inoperable and wouldn't respond to radiation or chemotherapy. He expected her to live only a few more months.

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The CU Sarcoma Clinic is pleased to welcome Breelyn A. Wilky, MD, to our multidisciplinary team. Dr. Wilky joined the Medical Oncology faculty in the cancer clinic on November 1, 2018.

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More than a stomachache

A trip to Jamaica means white sandy beaches, warm waters, and a perfect get away for most people. But for Stephen Estrada, a colon cancer patient at the University of Colorado Cancer Center, his trip to the island turned into a nightmare.

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An investigator from University of Colorado Cancer Center is being recognized for his contributions to the battle against lung cancer.

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In women at high risk for ovarian cancer, the common prevention strategy is to remove fallopian tubes and ovaries as soon as the woman is done having a family – the sooner the better. But this initiates menopause and along with it higher risk of cardiovascular disease, osteoporosis, sexual side-effects, and perhaps even Alzheimer’s disease. A recent University of Colorado Cancer Center review in the International Journal of Gynecologic Cancer suggests a way young, high-risk women can reduce risk while leaving menopause for later: the technique known as salpingectomy removes the fallopian tubes while leaving ovaries intact.

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When the going gets tough, grape seed extract gets going: A University of Colorado Cancer Center study recently published in the journal Cancer Letters shows that the more advanced are colorectal cancer cells, the more GSE inhibits their growth and survival. On the other end of the disease spectrum, GSE leaves healthy cells alone entirely.

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Nearly 12,000 people will die of head and neck cancer in the United States this year and worldwide cases will exceed half a million.

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One morning at 3 am and fairly early in his neurosurgery career at the University of Colorado School of Medicine, Dr. Kevin Lillehei got a phone call from Moscow. A mother was frantic about her daughter’s brain tumor. The doctors there had told her that the tumor was malignant and nothing further could be done. She wanted to know if Dr. Lillehei (pronounced Lily-hi) would see her daughter, Darya.

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