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AZD0156

Cancer    DNA    Irinotecan    AZD0156

Irinotecan breaks cancer cell DNA – AZD0156 keeps the body from repairing it

The chemotherapy drug irinotecan creates DNA damage leading to cell death and is used to treat colorectal cancer, among other cancer types. Now a University of Colorado Cancer Center study presented at the American Association for Cancer Research (AACR) Annual Meeting 2019 suggests a way to make irinotecan work even better: When researchers added the experimental drug AZD0156 to irinotecan, colorectal cancer cells and models of human colorectal cancer tumors grown in mice both showed significantly more cancer cell inhibition than with irinotecan used alone. An ongoing phase 1 clinical trial is currently testing the combination against advanced solid tumors (NCT02588105).


Author Cancer Center | Publish Date April 03, 2019
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CU Cancer Center In the News

OncLive

Camidge and Vokes Reflect on Research Journeys, Team Building, and Mentorship

news outletOncLive
Publish DateAugust 24, 2023

In this episode of "How This Is Building Me," Drs Camidge and Vokes discuss the span of countries and institutions along Dr Vokes’ journey to MD Anderson Cancer Center, how Dr Vokes balances research and work in the clinic, and how the correct mentors can help shape career paths in oncology.

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Colorado Public Radio

Community Gardening Can Also Grow a Bounty of Physical and Mental Health Benefits, a CU Study Finds

news outletColorado Public Radio
Publish DateAugust 15, 2023

Horse Barn Community Garden is in Five Points’ Curtis Park, near downtown Denver. This is where you’ll often find Charlotte Griffin, watering the vegetables.

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Science News

Why Are More People Under 50 Getting Colorectal Cancer? Scientists Have Some Clues

news outletScience News
Publish DateAugust 14, 2023
Many factors may be driving an uptick of the cancer among younger and middle-aged adults.
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Healio

Radiation-Immunotherapy Strategy Shows ‘Strong Efficacy Signal’ in Pancreatic Cancer

news outletHealio
Publish DateAugust 08, 2023

A novel therapeutic approach that combined radiation and immunotherapy demonstrated the ability to eliminate pancreatic tumors and halt metastases.

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