Cancer cells are even smarter than scientists previously believed, according to new CU Boulder research.
CU Boulder Today
CU Anschutz
Anschutz Cancer Pavilion
1665 North Aurora Court
2004
Aurora, CO 80045
Research Press Coverage Breast Cancer
Cancer cells are even smarter than scientists previously believed, according to new CU Boulder research.
For the past four years, University of Colorado Cancer Center member Sarah Tevis, MD, has focused her research on the psychosocial outcomes of breast surgery for women with breast cancer — specifically comparing patient-reported outcomes three and six months after receiving a lumpectomy (surgery in which just the tumor and some of the surrounding cells are removed) and a mastectomy (surgery to remove the entire breast).
Breast Cancer Colorectal Cancer cancer screening
Early detection of cancer plays a vital role in improving cancer survival rates. Detecting cancer early allows for timely intervention, stopping the cancer before it metastasizes, and increasing the effectiveness of treatment options.
At the University of Colorado Cancer Center, many members are focused on detecting cancer early by providing greater access to screening and educating the community on options.
Breast Cancer Public Health cancer screening
Driven in part by an increase in breast cancer diagnoses in younger women — particularly in Black women — the United States Preventive Services Task Force (USPSTF) — has proposed lowering the recommended age for beginning regular mammograms from 50 to 40. The USPSTF recommends that women at average risk for breast cancer get screening mammograms every other year.
Community Breast Cancer Surgical Oncology
For women with dense breasts, getting a mammogram to screen for breast cancer can be something of a double whammy. Not only is cancer more difficult to detect in dense breasts, but dense breasts also are a risk factor for developing breast cancer in the first place.
Breast Cancer Women's Health cancer screening
Mammograms are a vital tool for breast cancer screening. They can detect tumors even before a woman experiences signs or symptoms of cancer, and are sensitive enough to register changes to breast tissue as small as a grain of sand.
A significant body of research has shown that having regular mammograms can lower a woman’s risk of dying from breast cancer.
Community Breast Cancer Metastasis
Cancer becomes especially dangerous when it metastasizes — or spreads — to other parts of the body, including the brain. Breast cancer is more likely than many other cancers to spread to the brain, due in part to the large amounts of estrogen present in areas including the hippocampus, hypothalamus, and amygdala.
Research Patient Care Breast Cancer Plastic Surgery
Amanda Vegter did not have time for whatever it was that she felt on the side of her left breast.
She was six weeks into her fourth year of veterinary school, she had backpacking trips to go on with her boyfriend, walks to go on with her two dogs, plus plans for a summer externship in South Africa. She was busy and happy and it was probably nothing.
But that firm spot she first felt on her breast in January 2021 while working out at her boyfriend’s house didn’t just go away. Now she can look back and shake her head – of course it was breast cancer.
Patient Care Awareness Breast Cancer Surgical Oncology
Scarlet Doyle was 29 when she was diagnosed with angiosarcoma, a rare type of breast cancer. She had found a lump and had to advocate for herself to get her breast cancer diagnosis. After having her care transferred to the University of Colorado Cancer Center, she was seen by Breelyn Wilky, MD, associate professor of medical oncology and deputy associate director of clinical research at the CU Cancer Center, and Gretchen Ahrendt, MD, professor of surgical oncology.
Former “TODAY” show anchor Katie Couric revealed last week that she was diagnosed with breast cancer in summer 2022. Couric appeared on “TODAY” on October 3 to talk about her diagnosis, saying she was lucky her cancer was detected during a routine mammogram and urging other women to keep up with their mammograms.
Community Awareness Breast Cancer
Each year, about 27,000 women age 45 or younger are diagnosed with breast cancer in the United States. Of those, about 4% are pregnant at the time of their diagnosis.
Researchers at the University of Colorado Anschutz Medical Campus have discovered how to extract critical information about breast cancer tumors and disease progression by analyzing blood plasma rather than using more invasive tissue biopsies.
“This is simply a blood draw,” said the study’s senior co-author Peter Kabos, MD, associate professor of medicine in the medical oncology division at the University of Colorado School of Medicine and CU Cancer Center member. “This allows us to look under the surface to see the defining characteristics of the disease. The advantage is that we don’t need to do repeated tissue biopsies.”
Community Breast Cancer Lung Cancer
Deaths from COVID-19 and drug overdoses grabbed a lot of the headlines in 2021, but recently released numbers from the Colorado Department of Public Health and Environment show that cancer was still a leading cause of death in the state, and the number-one cause of death for the 45–84 age range.
After a 30-year, off-and-on battle with metastatic breast cancer, Australian-born actress and singer Olivia Newton-John died on August 8 at age 73. Best known for her role as Sandy in the 1978 movie musical “Grease,” Newton-John also hit the music charts with singles like “Physical” and “Magic.”
When the 21st Century Cures Act went into effect in April 2021, health care organizations began releasing electronic health information (EHI) to patients immediately.
A new study released by the University of Colorado Cancer Center shows that more than 70 percent of breast cancer patients have reported changes that affect their sexual health during and beyond treatment.
Artificial intelligence and machine learning are among the latest tools being used by cancer researchers to aid in detection and treatment of the disease.
Research Breast Cancer Genetics
PIK3CA is a gene that makes an enzyme called PI3K, which is involved in many important cell functions. When PIK3CA mutates, however, it can make the PI3K enzyme become overactive and cause cancer cells to grow.
Community Breast Cancer Colorectal Cancer
At first blush, the numbers aren’t great: Cancer patients who are covered by Medicaid tend to have later-stage disease and higher rates of mortality.
Research Breast Cancer Pediatric Cancer Melanoma Funding
The Tumor-Host Interactions Program (THI) at the University of Colorado Cancer Center has awarded four CU Cancer Center researchers $30,000 each to gain preliminary data using the Multiplex Ion Beam Imager (MIBI) housed in the cancer center’s Human Immune Monitoring Shared Resource (HIMSR) to support a competitive national grant proposal. The selected researchers are expected to submit a national competitive grant proposal within six months of completing their THI-MIBI pilot studies.
Can dietary strategies like intermittent fasting or time-restricted eating help breast cancer survivors prevent their tumors from recurring? It’s a question researchers at the University of Colorado (CU) Cancer Center are looking to answer with a new study funded by a $3 million R01 grant from the National Cancer Institute.
Breast Cancer Lung Cancer Colorectal Cancer
The American Cancer Society (ACS) released its annual cancer statistics last week, reporting that the risk of dying from cancer in the U.S. has fallen 32% over the past 28 years. Cancer deaths in the U.S. reached their peak in 1991, with 215 out of every 100,000 people dying from cancer, and have been falling ever since, largely due to a decline in the amount of people who smoke.
Research Patient Care Community Breast Cancer Magazine Surgical Oncology
When a woman receives a breast cancer diagnosis, she may have many questions about her immediate future – the stage of the disease, what treatment she’ll receive, where it will happen.
Patient Care Community Breast Cancer Advocacy
The first time Caley Kurchinski had to think about a double mastectomy, she was only 16. Her mother had died at age 36 from breast cancer, when Caley was 6. When she became a teenager, Caley’s family physician began telling her she needed to get genetic testing.
Patient Care Awareness Breast Cancer Surgical Oncology Plastic Surgery
Kirsten Stewart was just putting on lotion, like she does every morning after her shower. That particular morning, though, she noticed something different: a lump that hadn’t been there before and that definitely wasn’t normal. She was only 30 years old.
Breast cancer patients whose cancer spreads to the brain may soon have new treatment options, thanks to research led by CU Cancer Center member Diana Cittelly, PhD.
Though the two main histological types of breast cancer — lobular and ductal — are treated with the same hormonal therapies, women with lobular breast cancer often have recurrence or metastasis of the disease several years after their initial treatment.
A discovery by CU Cancer Center member Traci Lyons, PhD, is providing new hope for women with metastatic breast cancer.
The COVID-19 vaccines are beginning to significantly slow the spread of the virus, but the Pfizer and Moderna and vaccines are having an unforeseen consequence for breast cancer doctors. The vaccines often cause swelling in the armpit or underarm that can mimic the lumps associated with breast cancer, causing some women undue concern.
Patient Care Community Breast Cancer
It feels odd to use the phrase “perfect timing” when talking about a cancer diagnosis, but that’s exactly how Tonya Quinn describes her experience being diagnosed with breast cancer two years ago.
Research Patient Care Breast Cancer Surgical Oncology
Though breast cancer patients are now living longer than ever before, treatments for the disease can have wide-ranging effects on their long-term quality of life. Physical, social, and sexual wellbeing all can be impacted by radiation, chemotherapy, surgery, antiendocrine therapy and other challenges that go along with a breast cancer battle.
New research from CU Cancer Center member Jing Hong Wang, MD, PhD, and recent University of Colorado Immunology program graduate Rachel Woolaver, PhD, may help researchers develop more effective personalized immunotherapy for cancer patients.
In late 2019, two remarkable women were brought together by a shared experience that could only happen at the University of Colorado Anschutz Health & Wellness Center. Through their participation in the BFitBWell Program for cancer survivors, they found renewed strength and friendship.
The lab of CU Cancer Center investigator, Jennifer Richer, PhD, has been hot on the trail of new treatments against triple-negative breast cancer (TNBC), an especially dangerous form of the disease. Recently, the lab has been exploring changes that allow these breast cancer cells to hide from the immune system while traveling through the body to seed new sites of metastasis. This line of research is paying off, showing chains of events that make TNBC especially aggressive. The question has been where these chains can be broken – where are the weak links?
Phase III clinical trial results reported today in the New England Journal of Medicine and presented concurrently at the San Antonio Breast Cancer Symposium (SABCS) 2019 show the combination of the investigational drug tucatinib with standard of care treatment including the drugs trastuzumab and capecitabine nearly tripled one-year progression-free survival (33 percent vs. 12 percent), and nearly doubled the two-year overall survivor (45 percent vs. 27 percent) in women with HER2+ metastatic breast cancer. The international, multi-center trial, named HER2CLIMB (NCT02614794), builds on early development and clinical trials involving the University of Colorado Cancer Center.
Breast cancer patients and women undergoing cancer-preventive breast surgeries may consider combining these procedures with hysterectomy and/or ovarian removal. However, a University of Colorado Cancer Center study published in Breast Journal argues against this combined approach: Patients undergoing coordinated breast and gynecologic procedures had a significantly longer length of hospital stay, and higher complication, readmission, and reoperation rates compared with patients who underwent single site surgery.
Ashkenazi Jewish women have a 1-in-40 chance of carrying the BRCA mutation and these BRCA-positive women have an 80 percent lifetime risk of developing breast or ovarian cancer. A study by University of Colorado Cancer Center and Shaarei Zedek Medical Center, Israel presented at the European Society of Human Genetics Annual Meeting 2019 shows the importance of healthy women knowing their BRCA status, even when these women choose not to undergo prophylactic mastectomy: Of 63 Ashkenazi Jewish women unaware of their BRCA+ status at the time of breast cancer diagnosis, and 42 women who were aware they were BRCA+ prior to their breast cancer diagnosis (but had decided against surgical prevention), the women who knew their BRCA+ status were diagnosed with earlier stage breast cancer, needed less chemotherapy, less extensive surgery, and had greater overall 5-year survival (98 percent vs. 74 percent).
The growth of some breast cancers is driven by hormones like estrogen and progesterone. Other breast cancers are driven by changes in the gene HER2. Still some cancers are driven by both – and breast cancers whose growth can be controlled by hormonal receptors and HER2 can be especially tricky to treat. A University of Colorado Cancer Center phase 1b study presented at the American Society for Clinical Oncology (ASCO) Annual Meeting 2019 offers an attractive alternative to the chemotherapy that is often used with these patients: the three-drug cocktail of targeted treatments – tucatinib, palbociclib and letrozole – was overall well-tolerated and showed preliminary evidence of promising anti-cancer activity. Results support the continued development of the combination in an ongoing phase 2 clinical trial.
“I see this as a promising chemotherapy-free combination for patients who have been without good options, especially for those whose disease has spread to the brain,” says Elena Shagisultanova, MD, PhD, investigator at CU Cancer Center and the trial’s principal investigator.
Tucatinib is a targeted HER2 inhibitor; palbociclib stops cancer cells from rushing through the cell cycle required for fast proliferation; and the anti-hormonal drug letrozole restricts the ability of cancers to drive growth using estrogens. Previous work has shown that palbociclib and letrozole combine to kill more cancer cells than letrozole alone. And lab work by Shagisultanova and her mentor Virginia Borges, MD, at CU Cancer Center led them to believe that tucatinib should be a potent addition to this combination.
Results of the current trial show that the theory holds up in humans: of 20 patients enrolled on the study since November 2018, 14 remained on study as of 1/4/2019, five of which had been on the study more than 6 months. The goal of the phase 1b study was to explore the safety of this combination, with no patients experiencing side effects that required study withdrawal.
“All these patients have metastatic breast cancer and up to five different treatments before trying this trial. Also, 45 percent have brain metastases. In this population, our results look promising,” Shagisultanova says.
A phase 2 trial further exploring the combination is offered at CU Cancer Center, University of Arizona, Northwestern University, New Mexico Cancer Care Alliance, Stony Brook University, and University of Texas Health Science Center San Antonio.
Patient Care Faculty Breast Cancer
The use of textured breast implants during augmentation or reconstructive surgery can slightly increase a patient’s risk of developing Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL), a form of cancer that is distinct from other breast cancers. Now an article recently published in Aesthetic Surgery Journal formalizes the treatment strategy for this diagnosis, offering clear guidelines for plastic and oncologic surgeons. The National Comprehensive Cancer Network, U.S. Food and Drug Administration, and World Health Organization all recommend the surgical technique known as stepwise en bloc resection, which includes total capsulectomy (removing scar tissue around the implant), explantation (removal) of the implant, complete removal of any associated masses, and removal of any involved (proven by biopsy) or suspicious lymph nodes.
Triple-negative breast cancers are more likely than other breast cancer types to metastasize and are especially likely to go the brain in younger women. Researchers have tested various hypotheses to explain this danger. One idea that has gotten little attention is the thought that estrogen might be to blame. After all, triple negative breast cancers lack estrogen receptors (along with progesterone receptors and HER2, thus the name triple negative), and so these cancers can’t possibly be influenced by estrogen. Right?
Research Patient Care Breast Cancer
Study after study has shown that for cancer survivors, exercise is good. But what kind of exercise is best? A pilot study by Colorado researchers hints that group exercise and personal training may lead to similar physical gains, but that a specially designed class for cancer survivors incorporating group dynamics-strategies may increase quality of life beyond that of survivors using personal training. The study now results in a $718,000 grant from the American Cancer Society that will dramatically expand the program, including new offerings through University of Colorado Cancer Center at the Anschutz Health and Wellness Center.
Research Faculty Breast Cancer
A study by researchers at the University of Colorado Cancer Center and Oregon Health & Science University published today in the Journal of the American Medical Association Network shows that breast cancers diagnosed in young women within 10 years of giving birth are more likely to metastasize, and thus more likely to cause death, than breast cancers in young women who gave birth less recently or not at all.
Patient Care Breast Cancer Cancer Surgical Oncology
Last year when surgeon Gretchen Ahrendt, MD, was considering a move from the University of Pittsburgh to accept the position of Director of the Diane O’Connor Thompson Breast Center on the Anschutz Campus, she and her husband, Steven – also a surgical oncologist – agreed their three daughters would have to support the move.
OncLive
August 24, 2023
In this episode of "How This Is Building Me," Drs Camidge and Vokes discuss the span of countries and institutions along Dr Vokes’ journey to MD Anderson Cancer Center, how Dr Vokes balances research and work in the clinic, and how the correct mentors can help shape career paths in oncology.
Colorado Public Radio
August 15, 2023
Horse Barn Community Garden is in Five Points’ Curtis Park, near downtown Denver. This is where you’ll often find Charlotte Griffin, watering the vegetables.
Science News
August 14, 2023
Healio
August 08, 2023
A novel therapeutic approach that combined radiation and immunotherapy demonstrated the ability to eliminate pancreatic tumors and halt metastases.