Research Gynecologic Cancer Ovarian Cancer
Ovarian cancer is one of the leading causes of cancer death among women, with nearly 20,000 new diagnoses each year and around 12,740 deaths from the disease estimated in 2024, according to the American Cancer Society
Community Breast Cancer Ovarian Cancer
All women need to pay attention to their risk factors for breast cancer and ovarian cancer, but women of Eastern European (Ashkenazi) Jewish ancestry should be especially vigilant, says University of Colorado Cancer Center member Marie Wood, MD, as their risk for having a genetic variant in the BRCA1 or BRCA2 genes is increased, predisposing them to developing hereditary breast and ovarian cancer.
Colorectal Cancer Ovarian Cancer
Cancers located in the abdomen — including colorectal cancer, appendix cancer, gastric cancer, and gynecologic cancers such as certain types of ovarian cancer — can be difficult to treat with traditional chemotherapy when the tumors spread beyond the organ in which they originated.
Research Gynecologic Cancer Magazine Ovarian Cancer
Ovarian cancer is a growing area of research at the University of Colorado Cancer Center. A newly formed Ovarian Cancer Innovations Group, envisioned by Saketh Guntupalli, MD, and led by Kian Behbakht, MD, MBA, is taking a multipronged approach to studying the disease.
A pair of University of Colorado Cancer Center researchers have received a major grant to fund the next five years of their long-running research into a genetic risk factor for ovarian cancer that varies greatly across different ethnic communities – research that they hope will lead to better-targeted therapies.
Patient Care Magazine Ovarian Cancer
Amy Bibbey has two distinct lives. There’s the life she led before ovarian cancer, and there’s everything after diagnosis.
Research Ovarian Cancer Multiple Myeloma
Many of the side effects of cancer treatment are well-known, including nausea, fatigue, and weight loss.
Patient Care Ovarian Cancer Immunotherapy Genetics
People often tell Winona Williams that she’s brave, and she is. Ovarian cancer could easily become a dark cloud over her, shadowing every minute of every day.
Press Releases Pediatric Cancer Blood Cancer Brain and Spinal Cancer Ovarian Cancer
Three researchers from the University of Colorado Cancer Center have received grants from the V Foundation, a cancer research nonprofit founded in 1993 by college basketball coach Jimmy Valvano, who died of cancer.
Research Cancer Ovarian Cancer
One of the most impactful advancements during the past decade in treating ovarian cancer is the use of PARP inhibitors (short for poly adenosine diphosphate-ribose polymerase). PARP inhibitors are a type of cancer drug that blocks the PARP enzyme from helping to repair DNA damage in cancer cells.
Research Gynecologic Cancer Ovarian Cancer
After nearly four years of work, a group of researchers and clinicians from the University of Colorado (CU) published a paper this week in the Clinical Cancer Research that shares findings from research looking at how the composition of ovarian cancer tumors changes during chemotherapy and contributes to therapeutic response.
Philanthropy Gynecologic Cancer Cancer Ovarian Cancer
In July 2019, Emily McClintock Addlesperger was on vacation in Maine with her husband, Jason, when she felt sick and was airlifted to Portland with internal bleeding. A tumor on her ovary had burst. It was Monday. On Saturday, she passed away. Emily was 44 years old.
Research Women's Health Ovarian Cancer
Most ovarian cancer starts in fallopian tubes. Then it sloughs from its site of origin and floats around in fluid until finding new sites of attachment. It’s not easy for cancer cells to survive away from their moorings. Observations by ovarian cancer doctors at University of Colorado Cancer Center and elsewhere hint at how they might do it: These doctors have seen that ovarian cancer cells often collect in tissues with high fat content. Could these cells be somehow using fat to survive the journey from their point of origin to their sites of growth?
Clinical Trials Ovarian Cancer
Patients with recurrent, heavily pretreated ovarian cancer generally have few therapeutic options. Phase 1 clinical trials are considered by some providers as a “last hope.” Historically, there has been concern that there is little clinical benefit to these trials and high concern of toxicity, as these are typically first in human studies. However, these worries may be unnecessary. A University of Colorado Cancer Center study presented at the American Society of Clinical Oncology (ASCO) conference in Chicago indicates that there are therapeutic benefits for ovarian cancer patients that enroll in Phase 1 clinical trials.
Cure Today
July 12, 2024
University of Colorado Cancer Center member Dr. Steven Thorpe emphasizes the collaborative nature of treating soft tissue and bone sarcomas, highlighting the multidisciplinary efforts at CU School of Medicine's Department of Orthopedics and Children’s Hospital Colorado. He underscores the goal of not only curing the disease but also preserving function through advanced surgical techniques and modern therapies, ensuring patients maintain quality of life post-treatment. Thorpe stresses the importance of long-term outcomes, tailoring treatments to support patients’ aspirations beyond their cancer journey, especially for pediatric cases.
OncLive
July 08, 2024
CU Cancer Center member S. Lindsey Davis, MD, highlighted that the combination therapy of sapanisertib and alisertib showed marginal clinical benefit for patients with advanced solid tumors, correlative analyses suggested that apoptotic response and tumor immune cell infiltrate might influence clinical outcomes. The phase 1b study's expansion cohort indicated some positive outlying responses among patients and underscore the need for further research to tailor treatments for standout patients and explore rational combinations to enhance efficacy.
News Medical
June 19, 2024
A new study led by University of Colorado Cancer Center member Marco Del Chiaro, MD, PhD, reveals that nearly 5% of pancreatic adenocarcinoma patients achieved a pathological complete response (pCR) after pre-surgical chemotherapy or chemoradiotherapy. This significant finding indicates that patients with pCR have a 63% five-year survival rate, compared to 30% for those without pCR, suggesting the potential for tailored treatments to improve outcomes.
Cancer Network
June 14, 2024
In a conversation at the 2024 European Hematology Association Congress, CU Cancer Center member Manali Kamdar, MD, discussed potential future research on lisocabtagene maraleucel (liso-cel; Breyanzi) for mantle cell lymphoma (MCL) and other lymphoma subgroups. She highlighted findings from the phase 1 TRANSCEND NHL 001 trial, noting improved efficacy and safety in patients with fewer prior therapies and non-refractory disease, suggesting liso-cel's utility in earlier treatment lines and specific lymphoma subgroups.
Greg Glasgow
