While software development has long been compared to the craft of carpentry due to the need for a sturdy foundation and clear instructions, many in the field say garden analogies offer a way to address gaps and enhance practices.
While software development has long been compared to the craft of carpentry due to the need for a sturdy foundation and clear instructions, many in the field say garden analogies offer a way to address gaps and enhance practices.
At first glance, there don’t seem to be many similarities between humans and zebrafish, but the small freshwater minnows native to southeastern Asia have quickly become a favorite model organism in scientific research, allowing researchers to study human health, rare diseases, and treatment options.
Research Awareness Climate Science
Hot summer days and a large body of water might sound like a recipe for relief when temperatures soar, but the same conditions can make lakes, ponds, and inland swim beaches the ideal place for harmful algal bloom (HAB) events to flourish.
“Should I be taking a probiotic?” is a question that Maggie Stanislawski, PhD, assistant professor in the University of Colorado Department of Biomedical Informatics (DBMI), gets asked often.
Research Advancement Data analysis
Anybody who has ever experienced altitude sickness, even the mildest form known as acute mountain sickness, knows how debilitating it can be. Symptoms, which include lightheadedness, nausea, fatigue, and headache, most often occur at altitudes above 8,000 feet.
Lila is a registered purebred beagle, but depending on what company does her DNA testing, she might be part rottweiler, part American foxhound, or not a beagle at all.
Research Rheumatoid Arthritis Data analysis
With no cure or widely successful therapeutic options for patients with rheumatoid arthritis (RA), Fan Zhang, PhD, is looking to computational machine learning to identify new target treatments.
For geneticist Joanne Cole, PhD, food is life. Her love goes beyond trying a new recipe and seeking out new restaurants – it’s also in her work in the University of Colorado Department of Biomedical Informatics (DBMI), identifying the connection between genetics and nutrition.
Being able to follow a patient’s progression through a health system is an important factor for care in any nation, but it can be more difficult in developing countries that face greater technological and data-related challenges.
Exploring diverse ancestry is a critical factor in furthering medical research.
A new study published in Nature Genetics from researchers in the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine, in partnership with the University of California San Francisco and Stanford University, is the largest of its kind that focuses on ancestry correlations with biomedical traits and the first study to examine the role of genetic variants across diverse ancestries in regulating gene expression.
Researchers in the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine have reached a major milestone in developing standards and tools for creating phenopackets that may foster more innovation and advancement in the medical field by allowing health professionals to more easily collect and share data.
Research Equity Diversity and Inclusion Data analysis
Following an analysis of more than 20,000 articles by researchers in the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine, a major science publication is implementing new policies to improve the diversity of its sources.
Research Artificial Intelligence (AI)
As the world explores the new possibilities and uses of artificial intelligence (AI) tools like ChatGPT, researchers at the University of Colorado Department of Biomedical Informatics (DBMI) are integrating similar models into academic authoring.
Research Health equity Clinical Informatics Clinical decision support (CDS)
For years, David Albers, PhD, associate professor of biomedical informatics at University of Colorado School of Medicine, has been haunted by a friend’s death. It was long before Albers contemplated a career in health care, when he was an undergrad studying physics and taking music lessons in his spare time from accomplished jazz musician Tony Williams.
New research from the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine has identified 45 genes whose gene expression is associated with body mass index (BMI), many of which have not been explored in obesity research before, after conducting a study using a multiethnic cohort.
Researchers in the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine spearheaded an innovative method to synthesize and compile accurate information about COVID-19 since the onset of the global pandemic in 2020.
Research Blood Child & Adolescent
Using data from studies published in the medical literature over a 40-year time span, Peter DeWitt, PhD, a University of Colorado School of Medicine data scientist in the Department of Biomedical Informatics (DBMI), has developed an automated algorithm to address gaps in children’s blood pressure percentiles, providing a way to directly compare blood pressure measurements for children of the same age, sex, and height.
Research Innovation Faculty Medical imaging
Nicholas Dwork, PhD, assistant professor in the Department of Biomedical Informatics at the University of Colorado School of Medicine, has filed a provisional patent for a technology that could increase scan speeds of three-dimensional magnetic resonance imaging (MRI). The invention could lead to faster results, increase the clinical applications of MRIs, and ultimately improve patient care.
Toan Ong, PhD, associate professor of biomedical informatics at the University of Colorado School of Medicine, has been approved for a $1.05 million funding award from the Patient-Centered Outcomes Research Institute (PCORI) for a project that will improve methods of conducting research using electronic health records (EHRs).
Research Community Equity Diversity and Inclusion
From the University of Colorado Department of Biomedical Informatics (DBMI) offices on the top floor of the Anschutz Health Sciences Building, one sees sweeping views of Denver and the Rocky Mountains. DBMI Assistant Professor Katrina Claw, PhD, sees the lands that Native American tribes have called their home.
Research COVID-19 Faculty Public Health
Overflowing intensive care units. A shortage of personal protective equipment. A scramble for hospital beds and ventilators. Health care workers pushed to the brink. The COVID-19 pandemic laid bare many well-documented vulnerabilities of health care systems. The need for accurate and early clinical assessment of severity related to COVID-19 was vital to developing crisis standards of care to meet the growing pandemic. These standards of care are informed by mortality prediction models, which assess the risk of imminent death in patients.
Research Press Releases Education Clinical Research CU Medicine Today
Connecting basic science and medicine with clinical and translational scientists, the University of Colorado School of Medicine is introducing the Department of Biomedical Informatics (DBMI) to enhance clinical care through integrated computational technology, laboratory investigations, and artificial intelligence (AI).
GenomeWeb
September 22, 2023
Shawn O’Neil, a data engineer at the Translational and Integrative Sciences Lab (TISLab) at the University of Colorado School of Medicine and training coordinator with the US National Institutes of Health’s National COVID Cohort Collaborative, recently joined the Monarch Initiative, an open-source bioinformatics platform for matching phenotypes to genotypes.
National Institutes of Health (NIH)
September 18, 2023
The NCATS National COVID Cohort Collaborative (N3C), which includes DBMI faculty, powered two large studies that reinforced a potential link between metformin and less-severe COVID-19 outcomes. One study of EHRs from more than 6,600 adults found that those with type 2 diabetes who were taking metformin before developing COVID-19 were less likely to be hospitalized, need mechanical ventilation or die. A second study of people with either prediabetes or polycystic ovary syndrome (a condition commonly treated with metformin) showed that metformin use was linked to less severe COVID-19.
KFF Health News
September 14, 2023
“We see physicians working two to four hours every evening on their patient emails after their shift is over, and that’s not sustainable,” says CT Lin, DBMI secondary faculty member and chief medical information officer at University of Colorado Health, which has not yet adopted billing for email visits. “But we worry that patients with complex disease will stop messaging us entirely because of this copay risk.”
Nature
September 13, 2023
Transcriptome-wide association studies have helped uncover the role of individual genes in disease-relevant mechanisms, explain researchers from the CU Department of Biomedical Informatics. However, modern models of the architecture of complex traits predict that gene-gene interactions play a crucial role in disease origin and progression. Researchers introduce PhenoPLIER, a computational approach that maps gene-trait associations and pharmacological perturbation data into a common latent representation for a joint analysis and observe that diseases are significantly associated with gene modules expressed in relevant cell types, and our approach is accurate in predicting known drug-disease pairs and inferring mechanisms of action.
Kara Mason
