Scientists uncover molecular mechanism contributing to defective heart development in Down syndrome

A recent study by scientists at the University of Colorado Anschutz Medical Campus reports the discovery of a molecular mechanism contributing to defective heart development in Down syndrome. The research team, led by Dr. Kunhua Song, associate professor of medicine, employed a combination of experiments using human cells with and without trisomy 21 and a mouse model of Down syndrome to illuminate the molecular basis of impaired heart formation.