Could Nodal RT Explain Failure of ICIs in Head and Neck Cancer?

mmune checkpoint inhibitors (ICIs) have shown impressive efficacy in many different cancer types, but not in head and neck cancer. But it may not be the case that these drugs are ineffective in this cancer type; instead, it may be that the immune responses they elicit are being blunted by another concurrent treatment: elective nodal irradiation (ENI).