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Mindfulness Training Helped Participants Maintain Weight Loss in Pilot Study

Trial included meditation, body scans, mindfulness of routine activities and group discussions

minute read

by Chris Casey | March 23, 2026
Stylized image of mindfulness practices.

With over 70% of adults in the nation overweight or obese, the desire to drop pounds is a pervasive health concern. When a person manages to lose a few pounds, their quest tends to intensify: How do I keep it off?

GLP-1 drugs are surging as a quick way to shed unwanted pounds, but their long-term safety and efficacy as a weight-loss solution remains unclear.

Key points:

  • Obesity is a global epidemic. In the United States alone, 70% of adults are overweight or obese.
  • A study examined the feasibility of a mindfulness intervention to prevent weight regain in adults who had shed 7% of their body mass over the previous two months.
  • Results showed all participants in the seven-member group maintained their weight loss over the span of the eight-week mindfulness curriculum. 

Can learning new habits lead to better impulse control and changed behaviors, offering a pharmacological-free route to the “holy grail” of weight maintenance? Enter mindfulness, a practice rooted in Buddhist meditation techniques.

Mindfulness and Metabolic Syndrome

 

CU Anschutz was recently part of a multisite trial that examined whether a habit-based lifestyle program, including mindfulness practices, can produce sustained 24-month remission from metabolic syndrome. Metabolic syndrome is an array of conditions – including high blood pressure, high blood sugar and high cholesterol/triglyceride levels – that sharply increase the risk of heart disease and type 2 diabetes.

 

The study, published in JAMA Internal Medicine, involved 618 participants and four cohorts. At CU Anschutz, the four cohorts received a six-month, weekly to bi-weekly lifestyle intervention, followed by 18 monthly maintenance contacts.

 

In addition to teaching the participants how to notice behaviors and take pauses during their daily life, the intervention focused on separating judgments from emotions. “We often think about our emotions and thoughts, like saying, ‘I wish I weren’t so worried,’ or ‘It’s really bad to feel sad and cry,’” said Elizabeth Chamberlain, PhD, a CU Anschutz assistant professor of psychiatry and director of well-being programs at the CU Anschutz Health and Wellness Center. “We all have these stories and narratives about how we are supposed to feel. Through mindfulness practice, we begin to observe those states without putting judgments to it.”

 

The study results showed that this habit-based lifestyle program can reliably produce sustained 24-month remission of metabolic syndrome, a growing health problem. 

Recently, a small group of research participants at CU Anschutz successfully harnessed mindfulness skills to maintain their weight loss during a curriculum-based intervention. The eight-week, single-arm pilot and feasibility study, published in the American Journal of Health Behavior, involved seven women, ages 18 to 65, who had dropped 7% of their body mass over the previous two months.

The women then completed the KORU Mindfulness Program at the CU Anschutz Health and Wellness Center. The intervention included meditation, body scans, mindfulness of routine activities, mindful eating and group discussions.

“The whole point of mindfulness is to learn how to notice subtle sensations and thoughts and feelings before they get really big,” said Elizabeth Chamberlain, PhD, an assistant professor of psychiatry at the CU Anschutz School of Medicine, and study co-author.

Daily life is filled with stressors and emotional triggers that prompt people to mindlessly eat even when they aren’t hungry, she said. “This is the practice of how to notice, pause and ground yourself in the moment without getting caught up in the stories of what you think is happening.”

In the following Q&A, Chamberlain explains the basics of mindfulness, how mindfulness practices help shape lifestyle behavior changes, and where this field of study is headed.

The interview was condensed for length and clarity. 

Q&A Header

With obesity being such a persistent problem, why has there been a lack of effective strategies for preventing weight regain after weight loss?

Weight maintenance has always been the holy grail. Even in my practice, I see people who come in for weight loss and often they have had success with losing and then they gain it back. Maintenance is really difficult. Physiologically, our bodies gravitate toward set weights. But my area is much more about the behaviors and habits that we all have in relation to food. Food is so readily available, and we often eat for reasons other than hunger. We often have mindless ways in which we go about our days, including food.

When it’s readily available and we’re in a hurry, feel rushed or feeling stress, anxiety or boredom, if we haven’t thought about what and how we’re going to eat, it’s easy to fall into patterns. We might notice that our clothes feel a little tight, but we just keep going along until suddenly we can’t get in our pants anymore.

With food, there is a lot of high reward, especially the sweet, salty and fatty kinds. Our bodies are hardwired to crave those things because they helped us survive in the old days. But now food is so abundant, and even though we don’t need that much, our brains still operate in similar ways; it’s wired for very high-reward food. And then, from when we were kids, we associate food with things like parties and feeling good. So, we just get caught up in living our lives, and often we don’t pay close attention to exactly what we’re eating and the reasons we’re eating it or noticing our own satiety signals. 

What were some of the mindfulness exercises that the study participants performed?

They did breathing exercises and lots of different practices to ground into your senses and anchor in the moment. We did body scans, which are part of a mindfulness-based stress reduction, and the KORU curriculum incorporates that, too. A body scan is where you sit or lie down and you methodically notice and scan each part of your body. Like ‘How are my feet? What am I noticing? Is there tension? What emotions might be coming up?’ And then you go up to the knees and keep going up the full length of your body.

If you scan your body and notice where things are, when you begin to feel stress, if you feel certain things, you will notice it more readily because you’re paying attention to it or you’ve been doing that in a relaxed state. 

The study participants all succeeded in maintaining their weight loss over the eight weeks. What did you notice from the results?

There are two pieces to it. One is the participants were surprised that they enjoyed the curriculum as much as they did. They liked the practices and found them useful in a lot of parts of their lives. Because they found it useful, it translated to being more aware and practicing these tools and techniques in their daily lives. So, because they were more mindful on a daily and weekly basis for eight weeks, they were paying closer attention to what they ate, how they felt, how they reacted to things, which helped them to keep their weight stable. So, they didn’t engage in some of those more mindless, ‘Oh, I just feel really sad. I remember the last time I felt sad a piece of chocolate helped me feel better.’

Also, curiosity is one of the tenets of mindfulness-based practices. Because they were actively engaging in their curiosity, it helped them pay closer attention to, ‘Is this food really something that I want right now? What else am I looking for?’ So that really helped them to not overeat mindlessly, perhaps helping them manage their stress, too.

When we have prolonged stress, there are many physiological consequences. Stress is implicated in weight gain, and if a person’s stress can be managed more effectively, they may be able to manage their eating habits and their weight. I think that was the mediator for them. 

So, managing their daily stress levels was key to their success in keeping the weight off?

Yes. It was being aware and noticing and having tools to manage their stress and noticing maybe some reasons for eating other than hunger that they might engage in on a daily basis. That’s the biggest thing. That’s what I work with folks on the most, because they’ll associate it with stress, but it’s often other things, too. It’s noticing: Am I hungry? What else might be going on?

So, we practice engaging that curiosity and grounding into their breath and trying some different things. 

What was the mindset of the participants going into the study? Did they wish to continue their weight loss, or were they ready to focus exclusively on weight-loss maintenance?

People always want to lose more weight, so they’re always hopeful that it’ll happen. But we were very specific in this trial that this is really just to maintain your weight loss. The goal is not to lose more weight. We want to support you in maintaining the progress you’ve made. So that was very clear in the recruitment and in the messaging when we did the intervention. If they happened to lose more weight, that’s great, but that was not a goal of the study.

We didn’t recruit women specifically, but that’s how it turned out based on the other selection criteria. It turned out to be a happy accident that we had that variable control. That’s a variable to think about: Does it make a difference if people who identify as women feel more supported with other people who identify as women in a weight management group? I think it is important also because women tend to gain more and have less success with weight maintenance than men do in general. That was cited in the study as well. 

What’s next for this field of study? How should future trials be adjusted to gain more information?

 I think having more longitudinal data would be really helpful. If somebody gets an eight-week intervention, maybe the next steps would be following up in a year, two years, five years. Does the weight maintenance persist? And then we can maybe explore people who did have success more longitudinally and people who didn’t, and see what differences there were in their behaviors and practices. If they continue to do the practice on their own, of if they sought more mindfulness practices, I think that would be fascinating to find out because, again, eight weeks is not very long, and we know that weight loss tends to creep back on after a couple years of weight loss. 

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Elizabeth Chamberlain, PhD