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Clinical Research

Research    Clinical Research    Cardiology

CU Anschutz Set to Launch Gene Therapy Trials for Heart Disorder

It started in the early 1990s as a registry of patients with a heart condition. Today, data from more than 2,000 families with dilated cardiomyopathy is informing the next generation of therapies for this serious disease.

Together, cardiologist Luisa Mestroni, MD, and geneticist Matthew Taylor, MD, PhD, both professors in the Division of Cardiology at the University of Colorado School of Medicine, have helped thousands of patients in the clinic. They’ve also studied many of the over 50 genes associated with dilated cardiomyopathy (DCM). In the following Q&A, they explain their research and the gene therapy clinical trials that will be launching on the CU Anschutz Medical Campus during the first half of 2024.


Author Guest Contributor | Publish Date February 20, 2024
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Research    Mental Health    Clinical Research   

Can Sperm Carry Stress Signals to the Next Generation?

At the fall Block Party, when the center of campus erupted into a mass of people, booths and food trucks, some partygoers might have noticed an unusual guest milling around. An oversized sperm, waving and weaving through the lines of people, turned more than a few heads at the annual event.


Author Debra Melani | Publish Date January 10, 2024
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Patient Care    COVID-19    Clinical Research   

Paxlovid to the Rescue? What to Know About the COVID-19 Drug

As the holiday and peak respiratory seasons collide, and COVID-19 cases continue a steady, weeks-long climb, doctors want high-risk people to remember: Should COVID catch them in the coming days, one call to the doctor could save Christmas – or more.


Author Debra Melani | Publish Date December 05, 2023
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Clinical Research    Autoimmune disease    Multiple Sclerosis (MS)

Early Stage Cell Therapy Trial Shows Promise in Treating Progressive Multiple Sclerosis

University of Colorado Anschutz Medical Campus researchers are part of an international team that has shown that the injection of a type of stem cell into the brains of patients living with progressive multiple sclerosis (MS) is safe, well tolerated and has a long-lasting effect that appears to protect the brain from further damage.


Author Laura Kelley | Publish Date November 27, 2023
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Patient Care    Diabetes    Clinical Research   

Call for Type 1 Diabetes Screening Gains Momentum

With the largest universal screening programs in the country, researchers at the Barbara Davis Center for Diabetes (BDC) have known for years that testing all children for type 1 diabetes (T1D) could prevent the heartbreak and life-threatening complications that late-stage diagnosis can cause. Yet, until recently, they have often felt alone in their educational efforts.


Author Debra Melani | Publish Date November 22, 2023
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Clinical Research    Autoimmune disease   

Study Finds Incidence of Celiac Disease Higher Than Experts Thought

Celiac disease is an autoimmune disorder that damages the small intestine when gluten, a protein found in wheat, barley and rye, is ingested. According to a recent study published in The American Journal of Gastroenterology, the worldwide incidence rate among children is “extremely high,” but varies by region.


Author Guest Contributor | Publish Date November 17, 2023
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Patient Care    Colorectal Cancer    Clinical Research   

At the Forefront: Focusing On Rise in Early-Onset Colorectal Cancer

At its given pace, colorectal cancer will seize the No. 1 spot as the top killer of Americans aged 20 to 49 within seven years. Cases of the deadly cancer – its warning signs not often comfortably shared with friends or even doctors – have increased between 1% and 2% each year in that age group since 1990.


Author Staff | Publish Date September 14, 2023
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Clinical Research    Child & Adolescent    Research Pharmacy

New HIV Drug Formulation Could Improve Treatment Outcomes for Children Worldwide

Researchers at the University of Colorado Anschutz Medical Campus have helped confirm the dosing, safety and effectiveness of a drug formulation designed for treating children with human immunodeficiency virus (HIV).


Author Laura Kelley | Publish Date August 03, 2023
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COVID-19    COVID-19 Podcasts    Clinical Research   

Studying How to Treat, Identify Long COVID: CU Anschutz Takes the Lead

Between leading-edge research and the region’s first clinic to specialize in treating patients with long COVID symptoms, the University of Colorado Anschutz Medical Campus is at the forefront of providing care while seeking to understand this still-mysterious disease. 


Author Chris Casey | Publish Date July 11, 2023
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Health equity    Clinical Research   

Achieving Mental Health Equity Means Overcoming Flawed Policy-Shaping Data Systems

Research in health equity and social determinants seeks to understand disparities and affect real change, yet the national data collection systems investigators rely on for their work are incomplete and hardwired for structural racism, Shale Wong, MD, MSPH, told attendees of the 10th annual Colorado Clinical and Translational Sciences Institute academic summit on Sept. 14.


Author Guest Contributor | Publish Date September 19, 2022
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Mental Health    Clinical Research   

Can Science Curb an Alcohol Use Crisis? CU Anschutz Addiction Experts Bank On It

As the nation reels from a substance abuse crisis that’s shattering lives every day, scientists and clinicians across the University of Colorado Anschutz Medical Campus work diligently in their labs and clinics, hoping to prevent tragedies of addiction.


Author Debra Melani | Publish Date September 19, 2022
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Patient Care    Blood Cancer    Clinical Research    lymphoma

Rolling the Dice: Gamble Pays Off For Cancer Patient in CAR T-Cell Clinical Trial

Family, friends and positive attitudes helped Katherine Haug through months of failed attempts at ridding her body of cancer. Then a passionate doctor with an experimental treatment gave the wife, mother and grandmother a big reason to smile.


Author Debra Melani | Publish Date August 15, 2022
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Research    Press Releases    Neuroscience    Clinical Research    Clinical    Alzheimer's

Study Provides Insight into Vagus Nerve’s Link to Brain

Researchers at the University of Colorado Anschutz Medical Campus have shown a direct link between vagus nerve stimulation and its connection to the learning centers of the brain. The discovery may lead to treatments that will improve cognitive retention in both healthy and injured nervous systems.


Author Laura Kelley | Publish Date July 28, 2022
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Neuroscience    Clinical Research    Addiction    Clinical Trials

Surge in Alcohol Deaths Adds Urgency to CU Researcher’s Quest for Medication

A 25% jump in alcohol-associated deaths in the United States in 2020 doesn’t surprise Joseph Schacht, PhD. The clinical psychologist and neuroscientist at the University of Colorado Anschutz Medical Campus, who specializes in the treatment of alcohol and other addictive disorders, has seen an increase in patients whose drinking rose during the pandemic.


Author Laura Kelley | Publish Date April 05, 2022
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Neuroscience    Pharmacy    Clinical Research   

What's Slowing Medical Cannabis Clinical Research?

Artin (Art) Shoukas, PhD, a Johns Hopkins University professor emeritus, would have never dreamed he’d be using marijuana every night in his retirement years. He melts the medicinal form – mostly cannabidiol (CBD) with just a touch of tetrahydrocannabinol (THC) – under his tongue before dinner.


Author Debra Melani | Publish Date February 10, 2022
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Press Releases    Clinical Research   

University of Colorado Anschutz Medical Campus Named ‘Rare Disease Center of Excellence’

The University of Colorado Anschutz Medical Campus – home to Children’s Hospital Colorado, UCHealth University of Colorado Hospital and the CU School of Medicine – has been designated as a NORD Rare Disease Center of Excellence for its research and commitment to advance care for patients with rare diseases.


Author Staff | Publish Date February 08, 2022
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COVID-19    Blood    Clinical Research   

Genetic Markers May Predict Severity of COVID-19 Infection

Scientists at the University of Colorado School of Medicine, along with colleagues at UCHealth University of Colorado Hospital, have discovered specific genetic biomarkers that not only show who is infected with COVID-19, but offer insights into how severe the disease might be, filling a major diagnostic gap.


Author David Kelly | Publish Date October 26, 2021
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Patient Care    Clinical Research   

Newly Approved Alzheimer’s Drug Spurs Hope and Controversy

As controversy swirls around the first disease-modifying Alzheimer’s drug ever approved, top experts at the University of Colorado Anschutz Medical Campus see the move – for the most part – as a step forward.


Author Debra Melani | Publish Date June 15, 2021
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