When Rui Zhao, PhD, was in high school in China in the 1980s, she read an article that predicted the 21st century would be “the century of biology.”
Mark Harden
CU Anschutz
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Genetics Microbiology Biochemistry & Molecular Genetics
When Rui Zhao, PhD, was in high school in China in the 1980s, she read an article that predicted the 21st century would be “the century of biology.”
Cancer is a disease driven by gene mutations. These mutated genes in cancer fall into two major categories: tumor suppressors and oncogenes. Mutations in tumor suppressor genes can allow tumors to grow unchecked – a case of no brakes – while mutations in oncogenes can activate cell proliferation, pushing the gas pedal all the way to the floor.
Patient Care Ovarian Cancer Immunotherapy Genetics
People often tell Winona Williams that she’s brave, and she is. Ovarian cancer could easily become a dark cloud over her, shadowing every minute of every day.
As genetic counseling and genetic testing continue gaining importance in the world of cancer, the new co-director of hereditary cancers in the University of Colorado Cancer Center is aiming to increase awareness of these important resources for patients.
Research Breast Cancer Genetics
PIK3CA is a gene that makes an enzyme called PI3K, which is involved in many important cell functions. When PIK3CA mutates, however, it can make the PI3K enzyme become overactive and cause cancer cells to grow.
An enzyme that has been identified as instrumental in the progression of many types of cancer is meeting its match in inhibitors synthesized and evaluated by University of Colorado (CU) Cancer Center researchers.
Paul Norman, PhD, was born in the Midlands region of Central England in the county town of Shrewsbury, which, coincidentally, is also the birthplace of the naturalist and explorer, Charles Darwin. And like Darwin, Norman set out on a mission to categorize the diversity of life. Only, while Darwin concerned himself with things he could see – the beak shape of Galapagos finches, for example – Norman explores the diversity of cells hidden inside our bodies. Even more specifically, Norman, who recently joined University of Colorado Cancer Center as a mentored member, researches the diversity of tiny proteins that sit on the surface cancer cells. What seems little could be very big: Differences in these proteins across ethnicities could help to explain the differences in cancer rates between human cultures.
Cure Today
July 12, 2024
University of Colorado Cancer Center member Dr. Steven Thorpe emphasizes the collaborative nature of treating soft tissue and bone sarcomas, highlighting the multidisciplinary efforts at CU School of Medicine's Department of Orthopedics and Children’s Hospital Colorado. He underscores the goal of not only curing the disease but also preserving function through advanced surgical techniques and modern therapies, ensuring patients maintain quality of life post-treatment. Thorpe stresses the importance of long-term outcomes, tailoring treatments to support patients’ aspirations beyond their cancer journey, especially for pediatric cases.
OncLive
July 08, 2024
CU Cancer Center member S. Lindsey Davis, MD, highlighted that the combination therapy of sapanisertib and alisertib showed marginal clinical benefit for patients with advanced solid tumors, correlative analyses suggested that apoptotic response and tumor immune cell infiltrate might influence clinical outcomes. The phase 1b study's expansion cohort indicated some positive outlying responses among patients and underscore the need for further research to tailor treatments for standout patients and explore rational combinations to enhance efficacy.
News Medical
June 19, 2024
A new study led by University of Colorado Cancer Center member Marco Del Chiaro, MD, PhD, reveals that nearly 5% of pancreatic adenocarcinoma patients achieved a pathological complete response (pCR) after pre-surgical chemotherapy or chemoradiotherapy. This significant finding indicates that patients with pCR have a 63% five-year survival rate, compared to 30% for those without pCR, suggesting the potential for tailored treatments to improve outcomes.
Cancer Network
June 14, 2024
In a conversation at the 2024 European Hematology Association Congress, CU Cancer Center member Manali Kamdar, MD, discussed potential future research on lisocabtagene maraleucel (liso-cel; Breyanzi) for mantle cell lymphoma (MCL) and other lymphoma subgroups. She highlighted findings from the phase 1 TRANSCEND NHL 001 trial, noting improved efficacy and safety in patients with fewer prior therapies and non-refractory disease, suggesting liso-cel's utility in earlier treatment lines and specific lymphoma subgroups.