<img height="1" width="1" style="display:none" src="https://www.facebook.com/tr?id=799546403794687&amp;ev=PageView&amp;noscript=1">

From Memory Loss to Heart Disease, Stress and Insomnia Can Take a Toll

A sleep expert shares how today’s high-anxiety environment can have a detrimental effect on slumber and health

minute read

by Debra Melani | April 18, 2025
Graphic illustration of woman with dark hair on a white pillow covered in blankets below a starry night sky with a thought bubble full of gibberish
What you need to know:

April is Stress Awareness Month. See tips on recognizing and managing stress.

Worrying about tomorrow’s test or Friday’s work presentation could trigger stress and steal sleep from a person’s night or week. Generally, it’s no big deal. But what if stress never goes away, looming overhead like an ever-present rain cloud that bursts every night, soon after the head hits the pillow?

“There’s a really strong bi-directional relationship between stress and sleep,” said Stacey L. Simon, PhD, DBSM, associate professor of pulmonary and sleep medicine at the University of Colorado School of Medicine. “High levels of stress can increase arousal at bedtime, which makes it much more difficult to fall asleep.”

Stressors that rain down can be profound, such as worries about finances or the nation’s future, or mundane, such as a daily sense of overwhelm about work and home schedules.

“When we’re stressed, we may have intrusive negative thoughts that can make it hard to turn off our brain in order to relax and get to sleep,” said Simon, who studies sleep and circadian rhythms with a focus on women (who have a higher prevalence of insomnia) and teen girls (in hopes of changing behaviors for prevention).

“And then, conversely, when we don’t get enough sleep at night, that can impact our ability to regulate our emotions during the day and make us even more susceptible to stress.”

See related story: When a Gummy Won’t Do It: Tips to Maintaining a Sleep Cycle for Health

It’s a vicious cycle capturing more people in today’s changing times.

“There has been so much going on in the news recently that leaves a lot of people feeling stressed, uncertain, anxious,” said Simon, who works in the sleep clinic at Children’s Hospital Colorado and conducts studies with the Ludeman Family Center for Women’s Health Research on the CU Anschutz Medical Campus.

Mass shootings, social divisiveness, housing costs and environmental issues topped other concerns in the latest annual national survey on stress by the American Psychological Association. Over three-quarters of respondents cited the future of the nation as a major source of anxiety.

“It definitely sounds like it is impacting a lot of people,” Simon said. “And we know stress can impact our physical and mental health, so this is definitely concerning.”

Simon explained how lack of sleep affects health – from triggering weight gain and high cortisol levels to sabotaging memory and mental health – in the Q&A below. She discusses how to address slumber problems in an accompanying Q&A.

See more stories in the CU Anschutz Newsroom Sleep Series.

Q&A Header

How does stress specifically affect the body and thus sleep?

It really has a physiological effect across our whole body. Our heart rate might be faster. Our blood pressure might increase. We may start to breathe more quickly and even feel short of breath. Our muscles tend to contract and tighten. Stress can also result in muscle pain or headaches. Some people get GI upset. And those physical symptoms can also impact our sleep negatively.

What’s the hypothalamic-pituitary-adrenal (HPA) axis, and how does it factor into stress and poor sleep?

It’s a part of our body’s stress management system. In response to stress, the HPA axis releases cortisol. That’s a totally normal stress response and is very healthy, but when we’re experiencing chronic stress, then that HPA axis is in overdrive. And it’s releasing these really prolonged, high levels of cortisol, and unfortunately that can increase our health risks and affect our sleep.

Should people with sleep troubles have their cortisol levels tested?

Our cortisol levels change throughout the day, and so it’s not really feasible to do a blood test to test those levels (unless a doctor suspects a cortisol-related underlying disease). And I think that we can be a good judge of when we’re feeling that impact of chronic stress and then acknowledging that it may be time to address it by speaking with your health provider or a psychologist or counselor for stress-management strategies. Addressing it is probably more important than getting that specific number.

How can serious sleep issues affect physical health?

Chronically insufficient sleep or untreated sleep disorders can increase risks for a number of health problems, including excessive weight gain, cardiovascular disease and diabetes. Beyond those kinds of longer-term consequences, poor sleep can also negatively impact our immune system, so it makes it harder to fight off illness. And then definitely poor sleep can impact our emotion regulation and increase our risk for anxiety and depression symptoms.

So mental health can cause sleep problems, and sleep problems can cause mental health issues?

Yeah, it’s definitely this bi-directional relationship. But, on the flip side, if we treat sleep problems, sometimes that can benefit our mental health, and if we treat anxiety or depression, sometimes that has a benefit on sleep as well.

What’s the weight-gain connection?

There’s some evidence that when we are getting insufficient sleep, we may eat more. Also not getting enough sleep may impact our hormone regulation, including our appetite-regulating hormones. And when we’re awake late at night, it’s less likely that we’re going to be eating healthful foods. Unhealthful foods are common with late-night snacking. There’s also emerging evidence that the timing of when we eat is important as well, so eating late at night may have a particularly negative effect on our health.

How does poor sleep potentially affect memory?

There are functions of our brain when we sleep that really help to consolidate our memories (short bursts of brain wave activities called sleep spindles are a prime focus of research today and thought to play a significant role in memory consolidation and cognitive function). When working with adolescents, I’ll tell them: Don’t pull an all-nighter. Get a good night of sleep before the exam if you want to do really well. If we aren’t getting enough sleep, it impacts our attention, our concentration, which can also play into memory. And long-term, there is some emerging research suggesting that sleep problems may be a risk factor for developing memory disorders like Alzheimer’s.

Here comes the sun: Many experts agree on one effective way to help maintain circadian rhythms (your biological clock’s timing) for better sleep: Step outside and soak in some sun for a few minutes each morning. Some scientists also suggest catching a few rays in the evening, as the sun’s light fades to dusk.

What is the circadian rhythm connection?

Our circadian rhythms are our body’s internal clocks. The timekeeper of our body helps to regulate our sleep-wake cycles as well as other bodily functions across the 24-hour day. Our circadian system is regulated by the light-dark cycle and also other daily cues, such as the timing of our eating or our physical activity. If our sleep is disrupted due to stress, we may be spending more time awake at night, and that could impact circadian rhythms. Or if we’re scrolling on our phones during evening hours, that bright light from our electronic devices can delay circadian rhythms.

Is there a correlation between stress and stressful dreams?

Certainly, when we are stressed, we may be more susceptible to nightmares or stressful dreams. Stress can, physiologically, really impact our body and can result in night awakenings. We may feel like we have poorer sleep quality or that our sleep is more fragmented.

Can chronic stress lead to a chronic sleep problem?

Sometimes, we may be having a number of poor nights of sleep and try to compensate for that by allowing ourselves to sleep in later or take naps during the day. Or we might go to bed really early to try to catch up on that sleep, and sometimes that can have an unintended consequence of leading to more chronic sleep problems, such as insomnia, where you’re having a lot of difficulties falling asleep, staying asleep or having early morning awakening. So, yes, that can unfortunately lead to ongoing sleep problems.

This interview was edited for length and clarity.

Read more on how to address sleep problems.

Featured Experts
Staff Mention

Stacey Simon, PhD, DBSM