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Blogs

COVID-19

Data scientists in the spotlight

Melissa Haendel, PhD, professor in the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine, and her team of data scientists have been working at a lightning-fast pace for two years, unlocking some of the mysteries of long COVID. Not only have they been instrumental in the development of the largest national, publicly available HIPAA-limited dataset in U.S. history – the National COVID Cohort Collaborative (N3C) – but their research using the data is making headlines and getting the attention of the White House.

Research    Health equity

Director's Corner

Dear CCTSI research community,

I was so delighted to see many of you at our tenth annual CU-CSU Summit, which we held on September 14. Faculty and staff from every CCTSI partner institution were present, demonstrating the high level of engagement, enthusiasm and collaboration among all of our partners. The topic was Research in Health Equity and Social Determinants and we were fortunate to be able to meet at the beautiful new Elliman Conference Center in the Anschutz Health Sciences Building. Chancellor Elliman himself helped launch the conference and we had a full day of presentations, interactive sessions, discussions and a poster session.


Author Ronald J. Sokol, MD | Publish Date
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COVID-19

Finding Your Groove

Two years ago, many of us had never worked from home. Our research required the use of a laboratory, or interaction with colleagues, patients or communities. Our teaching and mentoring required face-to-face interaction with students or trainees. The COVID-19 pandemic turned all this upside down. In March 2020, tens of millions of American workers were instructed to work from home to prevent the spread of the virus that causes COVID-19. University campuses and healthcare systems closed academic offices and laboratories and directed scientists and staff to continue their work remotely if possible. We did not think this would last for long. However, here we are over two years later, and remote/hybrid (some office, some home) work continues for many.


Author Heather M. Gilmartin | Publish Date
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COVID-19   

Data scientists in the spotlight

Melissa Haendel, PhD, professor in the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine, and her team of data scientists have been working at a lightning-fast pace for two years, unlocking some of the mysteries of long COVID. Not only have they been instrumental in the development of the largest national, publicly available HIPAA-limited dataset in U.S. history – the National COVID Cohort Collaborative (N3C) – but their research using the data is making headlines and getting the attention of the White House.


Author Wendy Meyer | Publish Date
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Research

Sharing Deep and Specialized Knowledge

Our mission at the CCTSI is to help build research teams of the future, speed the development of new treatments and improve human health. Pediatric oncologist and researcher Dr. Mike Verneris exemplifies this mission through his work with the Consortium for Pediatric Cellular Immunotherapy (CPCI). It’s a mouthful, but the gist of it is a group of five children’s hospitals (and their research institutes like the CCTSI) are working together to share deep and specialized knowledge about developing cellular therapy to treat cancers and other pediatric illnesses.


Author Wendy Meyer | Publish Date
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Community    COVID-19   

CU Anschutz researchers work with Colorado communities to develop trustworthy and relevant COVID-19 information

The massive volume of messages we all have received about COVID-19 led the World Health Organization to coin the term “infodemic”: too much information, including false or misleading messages, in digital and physical environments during a disease outbreak. Though academics will be studying the toll of this misinformation for many years to come, we know it has been massive.


Author Wendy Meyer | Publish Date
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Research    Publications

Cystic Fibrosis News

Ten years ago, people with cystic fibrosis (CF) celebrated when the FDA approved ivacaftor, the first drug designed to target the defective protein that causes the disease. CF is an inherited disorder that inflicts severe damage to the lungs, digestive system and other organs in the body. Since then, several additional drugs that use a similar mechanism have been approved by the FDA for CF.


Author Wendy Meyer | Publish Date
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Press Releases   

CU Anschutz and Children’s Hospital Colorado lead national pandemic response project

Researchers are working to better prepare for the next pandemic.


Author Wendy Meyer | Publish Date
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Research    Education   

Pragmatic Research in Health Conference in May 2022

In 2020, the Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS) education program at the School of Medicine at the University of Colorado Anschutz Medical Campus, was awarded a three-year conference grant from the Agency for Healthcare Research and Quality (AHRQ). After successfully offering two virtual conferences in 2020 and 2021, ACCORDS, and co-sponsor Colorado Clinical and Translational Sciences Institute (CCTSI), are proud to offer the third annual Colorado Pragmatic Research in Health Conference (COPRH Con) on May 23-25, 2022, as a hybrid event. Anschutz Medical Campus employees and CCTSI members from affiliated institutions can attend this year’s conference for free.


Author Katie Klossner | Publish Date
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Research    Kudos

Matthew DeCamp, MD, PhD, takes on leadership role in research ethics

The Colorado Clinical and Translational Sciences Institute (CCTSI) is pleased to announce that Matthew DeCamp, MD, PhD, will assume the role as the new leader of its research ethics program. Marilyn Coors, PhD, who served in this role since 2010, recently retired from the University of Colorado Anschutz Medical Campus. Dr. DeCamp is associate professor in the Center for Bioethics and Humanities and Division of General Internal Medicine in the School of Medicine.


Author Wendy Meyer | Publish Date
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Research    Kudos

Bringing focus to research ethics for two decades

When Marilyn Coors, PhD, took a job as an assistant professor in the Center for Bioethics and Humanities at the University of Colorado Anschutz Medical Campus, she had a vision. She wanted the center to become an integral part of the operation of science, research and teaching on the state’s top medical campus. Today, more than 21 years later, it is clear her vision has been realized.


Author Wendy Meyer | Publish Date
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Press Releases    COVID-19   

Scientists’ Discovery is One Step Closer to More Effective COVID-19 Treatment with Immune Modulatory Drugs

A recent study published in the Proceedings of the National Academy of Sciences by a team of researchers at the University of Colorado Anschutz Medical Campus significantly advances the understanding of a key aspect of the immune system during COVID-19: the interferon response.


Author Chelsea Donohoe | Publish Date
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Pediatrics   

Inaugural Chief Scientific Officer, Child Health Announced

Children’s Hospital Colorado (Children’s Colorado), the University of Colorado School of Medicine (CU School of Medicine) and the University of Colorado Anschutz Medical Campus (CU Anschutz Campus) are announcing that Ronald J. Sokol, MD, will become the inaugural Chief Scientific Officer, Child Health, effective May 1, 2022. As an experienced research leader and expert in pediatric liver disease and transplantation, Dr. Sokol will help formalize a joint research enterprise across the CU Anschutz Campus to promote discovery and increase understanding of childhood diseases, while also advancing clinical care to improve health across the entire lifespan. 


Author Staff | Publish Date
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Press Releases    COVID-19   

Nationwide study of 'Long COVID' to launch at University of Colorado Anschutz Medical Campus

The National Institutes of Health (NIH) has invested nearly $470 million to build a national study population of diverse research volunteers and support large-scale studies on the long-term effects of COVID-19. The Colorado Clinical and Translational Sciences Institute (CCTSI) is playing a major role in the initiative called REsearching COVID to Enhance Recovery or RECOVER.


Author Wendy Meyer | Publish Date
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Research    Kudos

CU Anschutz biostatistician wins prize from Royal Statistical Society

You never know when inspiration will strike. For biostatistician Conner Jackson, MS, his inspiration was a pet tortoise named Pietro. Pietro’s owner insisted the tortoise could predict the weather through his behavior. The topic came up in a Zoom meeting one day and Jackson was captivated. “I expected everyone to say, ‘we should look into that!'"


Author Wendy Meyer | Publish Date
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Funding    Pilot Award

Five Tips to Securing a CCTSI Pilot Grant

The CCTSI Pilot Grant Program is probably the best-known of our CCTSI offerings. Yet, word on the street is that securing a pilot grant can be challenging. These one-year awards are certainly competitive—and we believe they are essential to catalyzing and accelerating translational research in Colorado. Our goal is to enable junior investigators, technology-experienced scientists and community-collaborative researchers to jumpstart their ideas, generate data, develop technologies for larger grants, clinical trials and ultimately improve patient care and public health.


Author Debra Szuster, MS | Publish Date
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Research    Kudos

Powering Research for 30 years

In 1991, Karen Morgenthaler started a new position working for Dr. Chip Ridgway in the endocrinology lab at the University of Colorado School of Medicine. After 30 years of service for the university, most of which took place in the lab at the Colorado Clinical and Translational Sciences Institute (CCTSI), Karen will retire at the end of 2021.


Author Wendy Meyer | Publish Date
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Research    Clinical Research

The top ten things you don’t know about the CCTSI

1. CCTSI stands for the Colorado Clinical and Translational Sciences Institute.

2. We help build the research teams of the future, speed the development of new treatments and improve human health


Author Wendy Meyer | Publish Date
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Research    Faculty

Five Tips to Protect Your Data

The pandemic has changed how we work. As a result, you may find yourself ferrying a laptop around more often. With this comes an increased risk it will be stolen, lost or damaged during transit. So, what are some things you can do to protect the sensitive data on your laptop? 


Author Matthew Latus | Publish Date
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Research    COVID-19

Lessons Learned During the Pandemic

In March of 2020, the pandemic drove Coloradans to enter lockdown mode. This was no different for researchers on the CU Anschutz Medical Campus. The result was that research operations were completely shuttered unless they were related to COVID-19 or essential to patient care.


Author Wendy Meyer | Publish Date
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Research    Press Releases   

New Study Reveals Serious Long-Term Complications in Youth-Onset Type 2 Diabetes

Phil Zeitler, MD, PhD, has been treating youth with type 2 diabetes for more than 20 years. He and a team of researchers published a paper today on the TODAY2 study in the New England Journal of Medicine on the long-term complications of type 2 diabetes. (TODAY stands for Treatment Options for type 2 Diabetes in Adolescents and Youth. The first phase of the study took place from 2004 - 2011; phase two from 2011 - 2020. Both studies involved more than 550 participants from across the country.)


Author Wendy Meyer | Publish Date
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Research    COVID-19

CCTSI COVID-19 Rapid Research Pilot Program

March 5, 2020 marked the anniversary of the first confirmed case of COVID-19 in Colorado. Just a few days later, on March 10, Governor Polis declared a state of emergency and soon thereafter most of us were working from home and living in full pandemic mode.


Author Wendy Meyer | Publish Date
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Research    Community    COVID-19    Pediatrics

CCTSI plays major role in vaccine clinical trials for children

As Colorado surpasses a 47 percent rate of its population being fully immunized (with 12 counties surpassing 70 percent), researchers continue to expand the study of the vaccines on children as young as five years old. The Pediatric Clinical and Translational Research Center (CTRC) and its nursing staff are playing a major role.


Author Wendy Meyer | Publish Date
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Research    Clinical Research    Kudos

CCTSI announces new leadership roles in clinical research

The CCTSI is pleased to announce two new leadership roles: Jose R. Castillo-Mancilla, MD and Christopher D. Baker, MD will each serve as Associate Medical Director of the Clinical and Translational Research Centers of the CCTSI. Dr. Baker will oversee the pediatric CTRC at Children’s Hospital Colorado under the leadership of Medical Director Dr. Phil Zeitler. Dr. Castillo-Mancia will oversee the adult CTRC at UCHealth under the leadership of Medical Director Dr. Tom Campbell.


Author Wendy Meyer | Publish Date
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COVID-19

Fully vaccinated older adults 94% less likely to be hospitalized with COVID-19

In vaccine clinical trials, the Pfizer and Moderna COVID-19 vaccines were shown to be about 95%  effective in preventing COVID-19. Now a study from the Centers for Disease Control and Prevention uses real-world data to show that indeed, those who are 65 years and older who are fully vaccinated are 94% percent less likely to be hospitalized for COVID-19 than those who have not been vaccinated. Researchers enrolled hospitalized patients from 20 hospitals across the nation—including UCHealth University of Colorado Hospital.


Author Wendy Meyer | Publish Date
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COVID-19    Health equity    Clinical Research

Emergency physician leads effort to reach and treat Coloradans with COVID-19

The nation has been coping with the pandemic for more than a year, and in this time, researchers have learned a great deal about how to treat COVID-19. Yet they have also been faced with what they still must learn, including how to reach the individuals who have been most dramatically impacted by the disease and who could benefit the most from new treatments. 


Author Wendy Meyer | Publish Date
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Community    COVID-19

Five Questions for Lilia Cervantes, MD

Associate Professor of Medicine Lilia Cervantes, MD is a homegrown success story, a physician researcher and a changemaker. Growing up in Denver and receiving her undergraduate degree from CU Boulder, she went on to earn her medical degree and complete her internal medicine residency at the CU School of Medicine. For the past 12 years, she has worked as an internal medicine hospitalist at Denver Health, the safety-net hospital in Denver. Dr. Cervantes’ research describes the worse outcomes of undocumented immigrants with kidney failure who rely only on emergency dialysis. As a result of Dr. Cervantes’ research and advocacy, in 2019 Colorado Medicaid opted to include the diagnosis of kidney failure as a qualifying condition under Emergency Medicaid, expanding access to standard dialysis. Recently, she published a qualitative study on the experiences of Latinx individuals hospitalized for COVID-19.


Author Wendy Meyer | Publish Date
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COVID-19

Reflections on a year of working from home during a worldwide pandemic

One year ago, CCTSI researchers and staff were told to continue our programs of research from home to keep ourselves, our colleagues, families and communities safe from COVID-19. Books and files were collected, labs were closed, clinical trials were put on hold, teaching and program management were moved online. Makeshift offices were created in closets, bedrooms, garages and on kitchen counters. I found myself at home with my husband and two teenagers. I continued my research where I could and connected with colleagues over Zoom while supporting my family through the COVID-19 lockdown.


Author Heather M. Gilmartin | Publish Date
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Research    COVID-19   

CU Anschutz Physician Publishes First Paper from Data in the National COVID Cohort Collaborative

They say necessity is the mother of invention. In terms of healthcare, one of the most remarkable inventions begat by the pandemic is something called the National COVID Cohort Collaborative (N3C). The vision of the scientists and researchers behind the N3C is to turn massive amounts of already available data into new knowledge urgently needed to study COVID-19 and identify potential treatments.

The speed at which the N3C has moved is astonishing: In just a little over six months, the initiative was launched, made available to biomedical researchers and has already produced its first publication.


Author Wendy Meyer | Publish Date
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Research    Community   

CU Researcher Tackles Vaccine Hesitancy in Colorado’s Religious Communities

Vaccine hesitancy is something we hear a lot about these days related to a potential coronavirus vaccine. Yet vaccine hesitancy has been a public health issue in the U.S. for many years. In 2019, a measles outbreak associated with vaccine refusal in religious communities infected 1,282 Americans—the most cases since 1992. And from 2006-2011, the rate of kindergarteners opting out of school-required vaccinations tripled.


Author Wendy Meyer | Publish Date
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Research   

CU Anschutz Launches Comprehensive Directory of Research Studies

Here at the Anschutz Medical Campus, we are in the business of answering important research questions in order to improve human health. One of the ways our physicians and scientists do this is through research studies that involve human participants who volunteer to make the studies possible.


Author Guest Contributor | Publish Date
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Research    Patient Care   

Finding the cause of a devastating polio-like illness

For some researchers who spend their days tucked away in a lab, the impact of their work may at times seem removed from the lives of real people. Not so for Dr. Kevin Messacar, pediatric infectious disease specialist. In his mind, he has considered himself a physician first, researcher second since he came to Children’s Hospital Colorado in 2009.


Author Guest Contributor | Publish Date
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Prove It: National Telehealth Research Network Greenlighted

The University of Colorado Anschutz Medical Campus is part of a team of researchers that has received a grant of $3.6 million for the SPROUT-CTSA Collaborative Telehealth Research Network


Author Guest Contributor | Publish Date
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Research   

Researchers discover a genetic defect linked to pediatric liver disease

Researchers from the University of  Colorado Anschutz Medical Campus, in collaboration with several other institutions, have discovered a genetic defect linked to Biliary atresia (BA), the most common pediatric cause of end-stage liver disease, and the leading indication for liver transplantation in children.


Author Staff | Publish Date
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Research   

Pioneering new eczema treatments

The battle between good and evil is a theme usually reserved for blockbuster movies or literature. However, biomedical researcher Donald Leung, MD, PhD, is engaged in his own epic battle, pitting good bacteria against bad in order to treat atopic dermatitis or eczema – the world’s most common skin disease.


Author Staff | Publish Date
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Colorado Clinical and Translational Sciences Institute (CCTSI) News Topics

Colorado Clinical and Translational Sciences Institute (CCTSI) In the News

5280

Inside Colorado’s Battle Against Rare Diseases

news outlet5280
Publish DateAugust 03, 2022

Melissa Haendel’s background in genetic research might be the key to coordinating rare disease information across the CU Anschutz Campus—and the world. Haendel is one of the leaders in the Colorado Clinical and Translational Sciences Institute (CCTSI).

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9News

Q&A: Nationwide long COVID-19 study needs more participants

news outlet9News
Publish DateAugust 03, 2022

A CCTSI study looking at the long-term side effects some patients are facing months after a positive COVID-19 test, a condition often called long COVID, is searching for more participants.

Full Story
Today

Prescription exercise?

news outletToday
Publish DateJune 06, 2022

In our new series Beyond the Scale, NBC’s John Torres reports for TODAY on a groundbreaking study at the National Institutes of Health that could help doctors prescribe personalized workout plans for patients.

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CNN

More than half of early Covid-19 patients at one hospital had symptoms two years later, study finds

news outletCNN
Publish DateMay 11, 2022

Even two years after their initial infection, the majority of people who were hospitalized with Covid-19 early in the pandemic had lingering symptoms, according to a new study that may be one of the longest and largest on record to follow people with long Covid.

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