The increase in syphilis cases shows the importance of public health, said Dr. Daniel Pastula, an associate professor of neurology, infectious disease and epidemiology at the University of Colorado School of Medicine and Colorado School of Public Health
“These patients are at particularly high risk for opioid overdose, as they are not receiving the protective effects of buprenorphine,” said Dr. Jarratt Pytell of University of Colorado School of Medicine, who led the study published Wednesday by JAMA Psychiatry.
Because the study was performed in a small number of people over a short period of time, the results don’t necessarily apply to the general population, said Dr. Dave Kao, a cardiologist and health data expert at the University of Colorado School of Medicine, who was not involved in the study. However, the study is consistent with others that have found coffee is safe and it offers a rare controlled evaluation of caffeine’s effect, Kao added.
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“I think the numbers provide data to confirm what we have expected to see and what we have been hearing from providers as well as supporters of people seeking abortion,” Kate Coleman-Minahan, an assistant professor at the University of Colorado College of Nursing said.
About 2.4 million adults are prescribed buprenorphine, a synthetic opioid, to address opioid use disorder, according to the report. In treatment, it substitutes for stronger opioids like heroin to prevent withdrawals. The end goal is for patients to then taper off use of buprenorphine as well. Discovering that some patients are undermining the treatment should be a red flag for clinicians, according to Jarratt Pytell, an assistant professor at the University of Colorado School of Medicine and co-author of the study.
“The more we've studied it, the more we realize that there's no level of lead in the diet or in intake that's without deleterious effects,” said Dr. Michael Kosnett, an associate clinical professor of medicine at the University of Colorado School of Medicine.
“Everyone’s brain works slightly differently, but we know in general triggers can cause a hyperexcitability to the cortex of the brain,” says Danielle Wilhour, an assistant professor in the Department of Neurology at the University of Colorado School of Medicine.
March 23, 2023